肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
1期
67-69
,共3页
肿瘤%基因,Klotho%抑癌基因
腫瘤%基因,Klotho%抑癌基因
종류%기인,Klotho%억암기인
Neoplasms%Gene,Klotho%Anti-tuomr gene
Klotho基因是20世纪末发现的具有抗衰老功能的新型基因,近些年来发现其在某些肿瘤中表达下调,如胃癌、肺癌、乳腺癌、子宫颈癌、皮肤癌、膀胱癌、结肠癌等,提高Klotho基因在这些癌细胞株中的表达可抑制肿瘤复制扩散能力,甚至使肿瘤细胞趋向凋亡,因此推测Klotho基因可能是一种具有抗肿瘤功能的新型基因.
Klotho基因是20世紀末髮現的具有抗衰老功能的新型基因,近些年來髮現其在某些腫瘤中錶達下調,如胃癌、肺癌、乳腺癌、子宮頸癌、皮膚癌、膀胱癌、結腸癌等,提高Klotho基因在這些癌細胞株中的錶達可抑製腫瘤複製擴散能力,甚至使腫瘤細胞趨嚮凋亡,因此推測Klotho基因可能是一種具有抗腫瘤功能的新型基因.
Klotho기인시20세기말발현적구유항쇠로공능적신형기인,근사년래발현기재모사종류중표체하조,여위암、폐암、유선암、자궁경암、피부암、방광암、결장암등,제고Klotho기인재저사암세포주중적표체가억제종류복제확산능력,심지사종류세포추향조망,인차추측Klotho기인가능시일충구유항종류공능적신형기인.
Klotho gene is a new gene found in the 20 century,which has a anti-aging function.Researchers people find that its expression in some tumors is down-regulated,such as in gastric cancer,lung cancer,breast cancer,cervical cancer,skin cancer,bladder cancer,colon cancer and so on.The ability of tumor' s replication and invasion could be inhibited through increasing the expression of Klotho gene,even be trended to apoptosis.So that the Klotho gene may be a new gene which has a anti-tumor function.
