肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
2期
115-118
,共4页
肝肿瘤%三维适形放射治疗%疗效
肝腫瘤%三維適形放射治療%療效
간종류%삼유괄형방사치료%료효
Hepatic neoplasms%Three-dimensional conformal radiotherapy%Result
目的 分析三维适形放疗(3D-CRT)治疗原发性肝癌的临床疗效.方法 对中晚期原发性肝癌81例采用3D-CRT,每次200～ 400 cGy,生物总剂量4800～5500cGy,中位剂量为4580 cGy,随访时间2～25个月.按WHO肿瘤疗效标准评价近期疗效.结果 81例均完成治疗,完全缓解21例,部分缓解46例,有效率82.7％(67/81).1、2年总生存率分别为43％、26％.多因素分析结果显示近期疗效、总剂量、是否远处转移、临床分期、肿瘤大小、Child分级对患者生存率有影响(均P＜ 0.05).结论 3D-CRT对原发性肝癌有较好的治疗作用,能够延长原发性肝癌患者的生存期.
目的 分析三維適形放療(3D-CRT)治療原髮性肝癌的臨床療效.方法 對中晚期原髮性肝癌81例採用3D-CRT,每次200～ 400 cGy,生物總劑量4800～5500cGy,中位劑量為4580 cGy,隨訪時間2～25箇月.按WHO腫瘤療效標準評價近期療效.結果 81例均完成治療,完全緩解21例,部分緩解46例,有效率82.7％(67/81).1、2年總生存率分彆為43％、26％.多因素分析結果顯示近期療效、總劑量、是否遠處轉移、臨床分期、腫瘤大小、Child分級對患者生存率有影響(均P＜ 0.05).結論 3D-CRT對原髮性肝癌有較好的治療作用,能夠延長原髮性肝癌患者的生存期.
목적 분석삼유괄형방료(3D-CRT)치료원발성간암적림상료효.방법 대중만기원발성간암81례채용3D-CRT,매차200～ 400 cGy,생물총제량4800～5500cGy,중위제량위4580 cGy,수방시간2～25개월.안WHO종류료효표준평개근기료효.결과 81례균완성치료,완전완해21례,부분완해46례,유효솔82.7％(67/81).1、2년총생존솔분별위43％、26％.다인소분석결과현시근기료효、총제량、시부원처전이、림상분기、종류대소、Child분급대환자생존솔유영향(균P＜ 0.05).결론 3D-CRT대원발성간암유교호적치료작용,능구연장원발성간암환자적생존기.
Objective To analyse the efficacy of three-dimensional conformal radiotherapy(3D-CRT)for hepatic carcinomas.Methods 81 patients with advanced hepatic carcinoma were treated at every turn of 200-400 cGy to a total dose of 4800-5500 cGy.Average-dose was 4580 cGy.Following up time was 225 monthes.Recent effect was evaluated according to WHO tumor evaluation standard.Results 81 patients accomplished the treatment.The local response rate was 82.7 ％(67/81)after treatment with 21 cases CR,46 cases PR.The 1,2 year overall survival rates were 43 ％,26 ％.In the multivariate analysis,the recent effect,the total dose,metastasis,clinical staging,the diameter of the tumors and Child grade presages had statistical significance for overall survival(all P ＜ 0.05).Conclusion 3D-CRT is preferable therapeutic action for primary hepatic carcinomas and can prolong the survival term.
