肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
3期
191-192
,共2页
乳腺肿瘤%男性%临床%分子亚型
乳腺腫瘤%男性%臨床%分子亞型
유선종류%남성%림상%분자아형
Breast neoplasms%Male%Clinical%Molecular subtypes
目的 研究男性乳腺癌(MBC)的发病因素、分子分型、手术方式等并对其预后进行评估.方法 回顾性分析近5年住院的MBC患者36例,选取同期女性乳腺癌(WBC)患者100例作为对照组,病理类型以浸润性导管癌为主；根据雌激素受体(ER)、孕激素受体(PR)和人类表皮生长因子受体2(Her-2)的表达情况将MBC分为4种分子亚型,即Luminal A型、Luminal B型、Her-2型和Basal-like型.结果 LuminalA组较LuminalB组乳腺癌患者组织学Ⅲ级的比例低,差异有统计学意义(x2=1.197,P＜ 0.05).结论 MBC发病率低,预后较差,病理类型以浸润性导管癌为主.MBC患者多见Luminal A型和Luminal B型,Luminal A型较Luminal B型乳腺癌患者组织学Ⅲ级的比例低.
目的 研究男性乳腺癌(MBC)的髮病因素、分子分型、手術方式等併對其預後進行評估.方法 迴顧性分析近5年住院的MBC患者36例,選取同期女性乳腺癌(WBC)患者100例作為對照組,病理類型以浸潤性導管癌為主；根據雌激素受體(ER)、孕激素受體(PR)和人類錶皮生長因子受體2(Her-2)的錶達情況將MBC分為4種分子亞型,即Luminal A型、Luminal B型、Her-2型和Basal-like型.結果 LuminalA組較LuminalB組乳腺癌患者組織學Ⅲ級的比例低,差異有統計學意義(x2=1.197,P＜ 0.05).結論 MBC髮病率低,預後較差,病理類型以浸潤性導管癌為主.MBC患者多見Luminal A型和Luminal B型,Luminal A型較Luminal B型乳腺癌患者組織學Ⅲ級的比例低.
목적 연구남성유선암(MBC)적발병인소、분자분형、수술방식등병대기예후진행평고.방법 회고성분석근5년주원적MBC환자36례,선취동기녀성유선암(WBC)환자100례작위대조조,병리류형이침윤성도관암위주；근거자격소수체(ER)、잉격소수체(PR)화인류표피생장인자수체2(Her-2)적표체정황장MBC분위4충분자아형,즉Luminal A형、Luminal B형、Her-2형화Basal-like형.결과 LuminalA조교LuminalB조유선암환자조직학Ⅲ급적비례저,차이유통계학의의(x2=1.197,P＜ 0.05).결론 MBC발병솔저,예후교차,병리류형이침윤성도관암위주.MBC환자다견Luminal A형화Luminal B형,Luminal A형교Luminal B형유선암환자조직학Ⅲ급적비례저.
Objective To analyze molecular classification and male breast cancer (MBC) triggers,clinical characteristics in patients with MBC and evaluate the prognosis.Methods 36 MBC patients enrolled in the past 5 years were retrospectively analyzed.100 patients with women breast cancer (WBC) in the same period were randomly selected as control group.The primary pathological type of MBC was the infiltrating ductal carcinoma.According to the expressions of estrogen receptor (ER),progesterone receptor (PR),and the epidermal growth factor receptor 2 (Her-2),the MBC can be divided into 4 kinds of molecular subtypes,Luminal type A,Luminal type B,Her-2 type,and Basal-like type.Results The ratio of MBC patients with grade Ⅲ was lower in the Luminal group A than that in the Luminal group B.There were significant differences (x2 =1.197,P ＜ 0.05) between these two groups.Conclusion The incidence rate of MBC is low but the prognosis is poor.The primary pathological type is the infiltrating ductal carcinoma.The ratio of MBC patients with grade Ⅲ is lower in the common Luminal group A than that in the common Luminal group B.
