肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
3期
211-213
,共3页
肿瘤%血管内皮抑素%新生血管化,病理性%凋亡%治疗
腫瘤%血管內皮抑素%新生血管化,病理性%凋亡%治療
종류%혈관내피억소%신생혈관화,병이성%조망%치료
Neoplasms%Endostatin%Neovascularization,pathologic%Apoptosis%Therapy
新生血管的生成在肿瘤的生长和转移中起重要作用,抗血管生成治疗已成为当今肿瘤治疗领域的热点,血管内皮抑素作为一种新型的内源性血管生成抑制剂,能特异性抑制内皮细胞的增殖和迁移,诱导细胞凋亡,并能抑制动物模型中新生血管生成,文章就内皮抑素的抗血管生成机制,诱导细胞凋亡及临床应用等方面进行综述.
新生血管的生成在腫瘤的生長和轉移中起重要作用,抗血管生成治療已成為噹今腫瘤治療領域的熱點,血管內皮抑素作為一種新型的內源性血管生成抑製劑,能特異性抑製內皮細胞的增殖和遷移,誘導細胞凋亡,併能抑製動物模型中新生血管生成,文章就內皮抑素的抗血管生成機製,誘導細胞凋亡及臨床應用等方麵進行綜述.
신생혈관적생성재종류적생장화전이중기중요작용,항혈관생성치료이성위당금종류치료영역적열점,혈관내피억소작위일충신형적내원성혈관생성억제제,능특이성억제내피세포적증식화천이,유도세포조망,병능억제동물모형중신생혈관생성,문장취내피억소적항혈관생성궤제,유도세포조망급림상응용등방면진행종술.
Angiogenesis plays an important role in tumor growth and metastasis,anti-angiogenic therapy is becoming the center point in tumor therapy,endostatin is a recently discovered endogenous inhibitor of angiogenesis.Endostatin can specifically target endothelial cells,inhibiting proliferation and migration and inducting apoptosis.This review describes the mechanism of endostatin in inhibiting angiogenesis,induction of apoptosis in tumor cells and clinical trials.
