肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
4期
217-219
,共3页
薛兴阳%赵健%周明%赵光日%傅文凡%杨嵘皓%孟江
薛興暘%趙健%週明%趙光日%傅文凡%楊嶸皓%孟江
설흥양%조건%주명%조광일%부문범%양영호%맹강
癌,非小细胞肺%免疫组织化学%nm23-H1%热休克蛋白27
癌,非小細胞肺%免疫組織化學%nm23-H1%熱休剋蛋白27
암,비소세포폐%면역조직화학%nm23-H1%열휴극단백27
Carcinoma,non-small-cell lung%Immunohistochemistry%nm23-H1%Heat shock protein 27
目的 分析nm23-H1和热休克蛋白27(HSP27)在非小细胞肺癌(NSCLC)发生、发展及转移中的作用.方法 应用免疫组织化学法检测75例NSCLC组织及28例良性肺病变中nm23-H1和HSP27的表达情况,并将检测结果与临床病理特征进行综合分析.结果 nm23-H1和HSP27的表达主要定位于细胞质,nm23-H1和HSP27在NSCLC中表达的阳性率分别为41.3 ％(31/75)和80.0％(60/75),明显高于良性肺病变7.1％(2/28)和46.4％(13/28)(x2=10.946,P=0.001；x2=11.131,P=0.001).NSCLC中HSP27蛋白的表达与肿瘤分化程度密切相关(x2 =4.191,P=0.041).肺癌组织中nm23-H1、HSP27的表达水平有相关性(r=0.284,P=0.013).结论 nm23-H1、HSP27与NSCLC的发生、发展有关,二者联合检测对肺癌的诊断和生物学行为判断有一定的意义.
目的 分析nm23-H1和熱休剋蛋白27(HSP27)在非小細胞肺癌(NSCLC)髮生、髮展及轉移中的作用.方法 應用免疫組織化學法檢測75例NSCLC組織及28例良性肺病變中nm23-H1和HSP27的錶達情況,併將檢測結果與臨床病理特徵進行綜閤分析.結果 nm23-H1和HSP27的錶達主要定位于細胞質,nm23-H1和HSP27在NSCLC中錶達的暘性率分彆為41.3 ％(31/75)和80.0％(60/75),明顯高于良性肺病變7.1％(2/28)和46.4％(13/28)(x2=10.946,P=0.001；x2=11.131,P=0.001).NSCLC中HSP27蛋白的錶達與腫瘤分化程度密切相關(x2 =4.191,P=0.041).肺癌組織中nm23-H1、HSP27的錶達水平有相關性(r=0.284,P=0.013).結論 nm23-H1、HSP27與NSCLC的髮生、髮展有關,二者聯閤檢測對肺癌的診斷和生物學行為判斷有一定的意義.
목적 분석nm23-H1화열휴극단백27(HSP27)재비소세포폐암(NSCLC)발생、발전급전이중적작용.방법 응용면역조직화학법검측75례NSCLC조직급28례량성폐병변중nm23-H1화HSP27적표체정황,병장검측결과여림상병리특정진행종합분석.결과 nm23-H1화HSP27적표체주요정위우세포질,nm23-H1화HSP27재NSCLC중표체적양성솔분별위41.3 ％(31/75)화80.0％(60/75),명현고우량성폐병변7.1％(2/28)화46.4％(13/28)(x2=10.946,P=0.001；x2=11.131,P=0.001).NSCLC중HSP27단백적표체여종류분화정도밀절상관(x2 =4.191,P=0.041).폐암조직중nm23-H1、HSP27적표체수평유상관성(r=0.284,P=0.013).결론 nm23-H1、HSP27여NSCLC적발생、발전유관,이자연합검측대폐암적진단화생물학행위판단유일정적의의.
Objective To detect the expressions of nm23-H1 and heat shock protein 27 (HSP27) and their clinical significance on development and metastasis in non-small cell lung carcinoma (NSCLC).Methods 75 tumor tissues from patients with NSCLC were included as experimental group and 28 pulmonary benign lesion tissues were as control group.The expressions of nm23-H1 and HSP27 in patients with different clinical and pathological characters were detected by immunohistochemistry.Results nm23-H1 and HSP27 were mainly expressed in cytoplasm,the positive rates of nm23-H1 and HSP27 were significantly higher in the experimental group than that in control group [41.3 ％ (31/75) vs 7.1％ (2/28),x2 =10.946,P =0.001,80.0 ％ (60/75) vs 46.4 ％ (13/28),x2 =11.131,P =0.001].Compared with control group,the positive rate of HSP27 was correlated with the degree of tumor differentiation (x2 =4.191,P =0.041).nm23-H1 was related with HSP27 in lung cancer (r =0.284,P =0.013).Conclusion nm23-H1 and HSP27 are related to the occurrence and development of NSCLC.The joint detection of nm23-H1 and HSP27 should be helpful to the diagnosis and judge the biological behavior of NSCLC.
