肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
5期
293-295,299
,共4页
杨凯%田文%董矜%董岩%李红
楊凱%田文%董矜%董巖%李紅
양개%전문%동긍%동암%리홍
结直肠肿瘤%脂肪酸类,不饱和%脂肪酸类ω-6%脂肪酸类ω-3%△6脱饱和酶
結直腸腫瘤%脂肪痠類,不飽和%脂肪痠類ω-6%脂肪痠類ω-3%△6脫飽和酶
결직장종류%지방산류,불포화%지방산류ω-6%지방산류ω-3%△6탈포화매
Colorectal neoplasms%Fatty acids,polyunsaturated%Fatty acids ω-6%Fatty acids ω-3%△6 desaturase
目的 了解结直肠癌患者多不饱和脂肪酸(PUFA)代谢状况,探讨PUFA代谢与△6脱饱和酶(D6D)的关系.方法 检测38例结直肠癌患者血红细胞及61例结直肠癌手术切除标本肿瘤组织PUFA的水平,分析ω-6和ω-3代谢途径各脂肪酸比例、D6D指数及两者关联性.结果 结直肠癌患者血红细胞及组织标本ω-6 PUFA代谢占优势,ω-6/ω-3 PUFA总比例分别为4.89和10.15；亚油酸/亚麻酸(LA/ALA)比值分别为101.92和86.16; ω-6/ω-3 LC-PUFA分别为2.86和4.51.ω-6代谢途径中D6D指数在肿瘤组织(t=11.609,P=0.00)及血红细胞(t=-9.151,P=0.00)中均高于ω-3途径代谢.结论 结直肠癌患者PUFA代谢以ω-6PUFA占优势,ω-6脂肪酸代谢途径较ω-3代谢途径活跃,与结直肠癌的发生、发展有一定的关系,可能为结直肠癌的防治提供一种手段.
目的 瞭解結直腸癌患者多不飽和脂肪痠(PUFA)代謝狀況,探討PUFA代謝與△6脫飽和酶(D6D)的關繫.方法 檢測38例結直腸癌患者血紅細胞及61例結直腸癌手術切除標本腫瘤組織PUFA的水平,分析ω-6和ω-3代謝途徑各脂肪痠比例、D6D指數及兩者關聯性.結果 結直腸癌患者血紅細胞及組織標本ω-6 PUFA代謝佔優勢,ω-6/ω-3 PUFA總比例分彆為4.89和10.15；亞油痠/亞痳痠(LA/ALA)比值分彆為101.92和86.16; ω-6/ω-3 LC-PUFA分彆為2.86和4.51.ω-6代謝途徑中D6D指數在腫瘤組織(t=11.609,P=0.00)及血紅細胞(t=-9.151,P=0.00)中均高于ω-3途徑代謝.結論 結直腸癌患者PUFA代謝以ω-6PUFA佔優勢,ω-6脂肪痠代謝途徑較ω-3代謝途徑活躍,與結直腸癌的髮生、髮展有一定的關繫,可能為結直腸癌的防治提供一種手段.
목적 료해결직장암환자다불포화지방산(PUFA)대사상황,탐토PUFA대사여△6탈포화매(D6D)적관계.방법 검측38례결직장암환자혈홍세포급61례결직장암수술절제표본종류조직PUFA적수평,분석ω-6화ω-3대사도경각지방산비례、D6D지수급량자관련성.결과 결직장암환자혈홍세포급조직표본ω-6 PUFA대사점우세,ω-6/ω-3 PUFA총비례분별위4.89화10.15；아유산/아마산(LA/ALA)비치분별위101.92화86.16; ω-6/ω-3 LC-PUFA분별위2.86화4.51.ω-6대사도경중D6D지수재종류조직(t=11.609,P=0.00)급혈홍세포(t=-9.151,P=0.00)중균고우ω-3도경대사.결론 결직장암환자PUFA대사이ω-6PUFA점우세,ω-6지방산대사도경교ω-3대사도경활약,여결직장암적발생、발전유일정적관계,가능위결직장암적방치제공일충수단.
Objective To study metabolism of polyunsantured fatty acid (PUFA) and to investigate the relationship between different PUFA compositions and △6 desaturase (D6D) activity in colorectal carcinoma (CRC).Methods Fresh frozen malignant CRC tissues were obtained from 61 patients and blood samples were detected in 38 patients.The PUFA composition in these samples was determined by gas-liquid chromatography on a capillary column.The fatty acid product-to-precursor ratios in blood and tissue as estimates of desaturase activity (D6D activity index),and its relationship with the ratios between different PUFA compositions were investigated.Results Metabolism of ω-6 PUFA dominated in PUFA metabolism path.The ratio of ω-6/ω-3 PUFA was 4.89 in blood samples and 10.15 in tissues.The ratio of LA/ALA was 101.92 in blood samples and 86.16 in tissues.The ratio of ω-6/ω-3 LC-PUFA was 2.86 in blood samples and 4.51 in tissues.The D6D activity index in ω-6 PUFA metabolic processes both in tissues (t =1 1.609,P =0.00) and blood samples (t =-9.151,P =0.00) were higher than that in ω-3 PUFA.Conclusion In colorectal carcinoma,the ω-6 PUFA metabolic not only plays an important role in the metabolism of PUFA,but also is more active than the ω-3 PUFA metabolic,and in some way links to the development of tumorigenesis in CRC.
