CAJ | 학술논문

目的分析病理T2～3N0食管癌临床病理特征对预后的影响.方法回顾性分析422例病理T2～3N0胸段食管癌患者的临床资料,应用Kaplan-Meier法进行单因素生存分析,组间比较用Log-rank 检验,多因素生存分析采用Cox模型分析.结果总的1、3和5年生存率分别为89.3％、63.5％、52.5％.单因素生存分析结果显示性别、肿瘤浸润深度和组织分化是影响食管癌预后的因素(x2值分别为7.45、7.79、15.81,均P＜0.01),Cox回归多因素生存分析显示性别、肿瘤浸润深度和组织分化也是食管癌预后的独立影响因素.结论性别、肿瘤浸润深度和组织分化是病理T2～3N0食管癌预后的独立影响因素,外科手术是病理T2～3N0食管癌的标准治疗方法.
목적 분석병리T2～3N0식관암림상병리특정대예후적영향.방법 회고성분석422례병리T2～3N0흉단식관암환자적림상자료,응용Kaplan-Meier법진행단인소생존분석,조간비교용Log-rank 검험,다인소생존분석채용Cox모형분석.결과 총적1、3화5년생존솔분별위89.3％、63.5％、52.5％.단인소생존분석결과현시성별、종류침윤심도화조직분화시영향식관암예후적인소(x2치분별위7.45、7.79、15.81,균P＜0.01),Cox회귀다인소생존분석현시성별、종류침윤심도화조직분화야시식관암예후적독립영향인소.결론 성별、종류침윤심도화조직분화시병리T2～3N0식관암예후적독립영향인소,외과수술시병리T2～3N0식관암적표준치료방법.
Objective To analyze the clinicopathologic features of patients with pathologic T2-3N0 thoracic esophageal squamous cell carcinoma (ESCC) and correlation to their prognosis.Methods The clinicopathologic data of 422 patients with pathologic T2-3N0 thoracic ESCC,who were treated with surgery were analyzed.Cumulative survival rate was analyzed by the Kaplan-Meier method and compared by Log-rank test.Cox regression model was used for multivariate prognostic analysis.Results The overall 1-,3-and 5-year survival rates were 89.3 ％,63.5 ％ and 52.5 ％,respectively.Univariate analysis revealed that the factors affecting the prognosis included gender (x2 =7.45,P ＜ 0.01),depth of invasion (x2 =7.79,P ＜ 0.01) andtissues differentiation (x2 =15.81,P ＜ 0.01).They were also independent prognostic factors according Cox regression multivariate survival analysis.Conclusion The gender,depth of invasion and differentiation should be independent prognostic factors of pathologic T2-3N0 ESCC.Surgery is still the standard treatment for pathologic T2-3N0 esophageal cancer.