肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
6期
393-395
,共3页
胃肠道间质瘤%免疫组织化学%CD117%CD34%Ki-67
胃腸道間質瘤%免疫組織化學%CD117%CD34%Ki-67
위장도간질류%면역조직화학%CD117%CD34%Ki-67
Gastrointestinal stromal tumors%Immunohistochemical%CD117%CD34%Ki-67
目的 探讨胃间质瘤的临床病理和免疫组织化学特征.方法 观察105例胃间质瘤的病理形态特征,并用免疫组织化学EnVision法检测CD117、CD34、SMA、S-100、Ki-67的表达.结果 CD117、CD34、SMA、S-100、Ki-67阳性表达率分别为85.7％(90/105)、93.3％(98/105)、20.4％(21/105)、12.4％(13/105)、56.1％(60/105).结论 联合检测CD117和CD34可以提高胃间质瘤的诊断准确性,Ki-67阳性表达与肿瘤大小、核分裂象、危险程度相关,可作为胃间质瘤的预后指标.
目的 探討胃間質瘤的臨床病理和免疫組織化學特徵.方法 觀察105例胃間質瘤的病理形態特徵,併用免疫組織化學EnVision法檢測CD117、CD34、SMA、S-100、Ki-67的錶達.結果 CD117、CD34、SMA、S-100、Ki-67暘性錶達率分彆為85.7％(90/105)、93.3％(98/105)、20.4％(21/105)、12.4％(13/105)、56.1％(60/105).結論 聯閤檢測CD117和CD34可以提高胃間質瘤的診斷準確性,Ki-67暘性錶達與腫瘤大小、覈分裂象、危險程度相關,可作為胃間質瘤的預後指標.
목적 탐토위간질류적림상병리화면역조직화학특정.방법 관찰105례위간질류적병리형태특정,병용면역조직화학EnVision법검측CD117、CD34、SMA、S-100、Ki-67적표체.결과 CD117、CD34、SMA、S-100、Ki-67양성표체솔분별위85.7％(90/105)、93.3％(98/105)、20.4％(21/105)、12.4％(13/105)、56.1％(60/105).결론 연합검측CD117화CD34가이제고위간질류적진단준학성,Ki-67양성표체여종류대소、핵분렬상、위험정도상관,가작위위간질류적예후지표.
Objective To investigate the clinicopathologic and immunohistochemical features of gastric stromal tumors.Methods A total of 105 cases with gastric stromal tumors were included in the study.The expression of cluster of differentiation 117 (CD117),cluster of differ entiation 34 (CD34),smooth muscle actin (SMA),S-100 protein and Ki-67 in gastric stromal tumors specimens was detected by immunohistochemistry.The clinico-pathologic features of gastric stromal tumors were also analyzed.Results Of 105 gastric stromal tumors specimens,90 were positive for CD117 [85.7 ％ (90/105)],98 positive for CD34 [93.3 ％ (98/105)],21 positive for SMA [20.4 ％ (21/105)],60 positive for Ki-67 [56.1％ (60/105)],13 positive for S-100 [12.4 ％ (13/105)].Conclusion Combined detection of CD117 and CD34 can improve the diagnostic accuracy of gastric stromal tumors.The expression of Ki-67 can be used as a prognostic parameter for gastric stromal tumors as it is correlated with tumor size,risk and mitotic.
