肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
6期
408-409,412
,共3页
子宫颈原位腺癌%免疫组织化学%液基细胞学
子宮頸原位腺癌%免疫組織化學%液基細胞學
자궁경원위선암%면역조직화학%액기세포학
Adenoearcinomas in situ of the cervix%Immunohistochemistry%Liquid based cytology
目的 探讨子宫颈原位腺癌的病理诊断特点.方法 应用液基细胞学(TCT)、活组织检查及免疫组织化学等方法对6例子宫颈原位腺癌进行分析.结果 3例TCT结果为鳞状上皮内高度病变,活组织检查为原位腺癌,伴不典型增生2级(CIN2)；2例TCT结果为非典型腺细胞,倾向瘤变,活组织检查为原位腺癌同时伴CIN3；1例TCT结果为上皮内高度病变,活组织检查后证实为CIN3,行锥切术,于锥切标本中发现子宫颈原位腺癌.免疫组织化学:癌胚抗原(CEA)异常腺体阳性表达,高Ki-67指数和p16弥漫强阳性染色,VIM间质阳性表达,腺体阴性表达,雌激素受体(ER)、孕激素受体(PR)阴性表达.结论 子宫颈原位腺癌的病理诊断主要依赖HE染色的镜下特征性表现,同时辅以免疫组织化学染色.子宫颈原位腺癌患者几乎均伴发CIN的改变.
目的 探討子宮頸原位腺癌的病理診斷特點.方法 應用液基細胞學(TCT)、活組織檢查及免疫組織化學等方法對6例子宮頸原位腺癌進行分析.結果 3例TCT結果為鱗狀上皮內高度病變,活組織檢查為原位腺癌,伴不典型增生2級(CIN2)；2例TCT結果為非典型腺細胞,傾嚮瘤變,活組織檢查為原位腺癌同時伴CIN3；1例TCT結果為上皮內高度病變,活組織檢查後證實為CIN3,行錐切術,于錐切標本中髮現子宮頸原位腺癌.免疫組織化學:癌胚抗原(CEA)異常腺體暘性錶達,高Ki-67指數和p16瀰漫彊暘性染色,VIM間質暘性錶達,腺體陰性錶達,雌激素受體(ER)、孕激素受體(PR)陰性錶達.結論 子宮頸原位腺癌的病理診斷主要依賴HE染色的鏡下特徵性錶現,同時輔以免疫組織化學染色.子宮頸原位腺癌患者幾乎均伴髮CIN的改變.
목적 탐토자궁경원위선암적병리진단특점.방법 응용액기세포학(TCT)、활조직검사급면역조직화학등방법대6례자궁경원위선암진행분석.결과 3례TCT결과위린상상피내고도병변,활조직검사위원위선암,반불전형증생2급(CIN2)；2례TCT결과위비전형선세포,경향류변,활조직검사위원위선암동시반CIN3；1례TCT결과위상피내고도병변,활조직검사후증실위CIN3,행추절술,우추절표본중발현자궁경원위선암.면역조직화학:암배항원(CEA)이상선체양성표체,고Ki-67지수화p16미만강양성염색,VIM간질양성표체,선체음성표체,자격소수체(ER)、잉격소수체(PR)음성표체.결론 자궁경원위선암적병리진단주요의뢰HE염색적경하특정성표현,동시보이면역조직화학염색.자궁경원위선암환자궤호균반발CIN적개변.
Objective To investigate the characteristics of pathological diagnosis of cervical adenocarcinoma in situ.Methods The liquid-based cytology (TCT),biopsy and immunohistochemical were analyzed in 6 cases of cervical adenocarcinoma in situ.Results There were 3 cases of TCT with high grade squamous intraepithelial lesion,and biopsy for adenocarcinoma in situ with CIN2.The results were atypical glandular cells (tendency of neoplasia) of TCT in 2 cases,and biopsy for adenocarcinoma in situ with CIN3.The last one was checked with high grade squamous intraepithelial lesion,and biopsy confirmed CIN3,but cervical adenocarcinoma in situ was found in conization of specimens.Immunohistochemistry result showed CEA positive expression,higher Ki-67 index and p16 strong positive staining,VIM negative expression,ER and PR negative expression.Conclusion Pathological diagnosis of cervical adenocarcinoma in situ is mainly dependented on the features of HE staining,supplemented by immunohistochemical staining.The pathological change of CIN is always associated with cervical adenocarcinoma in situ.
