肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
7期
472-474
,共3页
肿瘤%等效均匀剂量%危及器官%放射治疗计划,计算机辅助
腫瘤%等效均勻劑量%危及器官%放射治療計劃,計算機輔助
종류%등효균균제량%위급기관%방사치료계화,계산궤보조
Neoplasms%Equivalent uiform dose%Organ at risk%Radiotherapy planning,computer-assisted
目的 探讨等效均匀剂量(EUD)优化方法对肿瘤调强放疗计划中危及器官的保护作用.方法 从已接受调强放疗的患者中用整群随机数字表法抽取鼻咽鳞状细胞癌8例、食管鳞状细胞癌10例、直肠癌6例,用物理约束条件优化设计放疗计划,将危及器官的物理约束条件改为EUD约束,同时保持靶区约束条件不变,为每例患者设计一个新计划,并比较新(PLANEU组)、旧(PLANNo_EUD组)治疗计划.结果 PLANEUD组8例鼻咽癌患者危及器官都得到了更好的保护,与PLANNOEUD组比较差异均有统计学意义(t值分别为2.590、2.352、3.656、2.148、2.283、3.683、2.192、2.353、2.146、2.276、2.126,均P＜ 0.05);10例食管癌患者危及器官受量两组比较,差异无统计学意义(t值分别为0.408、0.427、0.902,均P＜ 0.05)；PLANEUD组6例直肠癌患者危及器官得到了更好的保护,与PLANNOEUD组比较差异均有统计学意义(t值分别为2.332、2.693、2.279、2.244,均P＜ 0.05).结论 在保证靶区剂量的同时,EUD优化方法能够降低危及器官的受照剂量,对减少正常组织放疗并发症具有重要意义,同时为靶区增量提供了空间.
目的 探討等效均勻劑量(EUD)優化方法對腫瘤調彊放療計劃中危及器官的保護作用.方法 從已接受調彊放療的患者中用整群隨機數字錶法抽取鼻嚥鱗狀細胞癌8例、食管鱗狀細胞癌10例、直腸癌6例,用物理約束條件優化設計放療計劃,將危及器官的物理約束條件改為EUD約束,同時保持靶區約束條件不變,為每例患者設計一箇新計劃,併比較新(PLANEU組)、舊(PLANNo_EUD組)治療計劃.結果 PLANEUD組8例鼻嚥癌患者危及器官都得到瞭更好的保護,與PLANNOEUD組比較差異均有統計學意義(t值分彆為2.590、2.352、3.656、2.148、2.283、3.683、2.192、2.353、2.146、2.276、2.126,均P＜ 0.05);10例食管癌患者危及器官受量兩組比較,差異無統計學意義(t值分彆為0.408、0.427、0.902,均P＜ 0.05)；PLANEUD組6例直腸癌患者危及器官得到瞭更好的保護,與PLANNOEUD組比較差異均有統計學意義(t值分彆為2.332、2.693、2.279、2.244,均P＜ 0.05).結論 在保證靶區劑量的同時,EUD優化方法能夠降低危及器官的受照劑量,對減少正常組織放療併髮癥具有重要意義,同時為靶區增量提供瞭空間.
목적 탐토등효균균제량(EUD)우화방법대종류조강방료계화중위급기관적보호작용.방법 종이접수조강방료적환자중용정군수궤수자표법추취비인린상세포암8례、식관린상세포암10례、직장암6례,용물리약속조건우화설계방료계화,장위급기관적물리약속조건개위EUD약속,동시보지파구약속조건불변,위매례환자설계일개신계화,병비교신(PLANEU조)、구(PLANNo_EUD조)치료계화.결과 PLANEUD조8례비인암환자위급기관도득도료경호적보호,여PLANNOEUD조비교차이균유통계학의의(t치분별위2.590、2.352、3.656、2.148、2.283、3.683、2.192、2.353、2.146、2.276、2.126,균P＜ 0.05);10례식관암환자위급기관수량량조비교,차이무통계학의의(t치분별위0.408、0.427、0.902,균P＜ 0.05)；PLANEUD조6례직장암환자위급기관득도료경호적보호,여PLANNOEUD조비교차이균유통계학의의(t치분별위2.332、2.693、2.279、2.244,균P＜ 0.05).결론 재보증파구제량적동시,EUD우화방법능구강저위급기관적수조제량,대감소정상조직방료병발증구유중요의의,동시위파구증량제공료공간.
Objective To evaluate the effect of an equivalent uiform dose optimization (EUD) based optimization algorithm in sparing the organ at risk (OAR) of tumor treated with intensity-modulated radiation therapy (IMRT).Methods 10 patients of nasopharyngeal carcinoma (NPC),10 patients of esophagus cancer,6 patients of rectum cancer were randomly selected from all patients received IMRT treatment.Then physical optimization constraints (dose/dose-volume constraints) were designed as EUD optimization,while the physical objectives for targets and other OAR were unchanged.Results There was statistically significant difference in protecting OAR in 8 NPC patients of PLANED group compared with those of PLANNO_EuD group (t values were 2.590,2.352,3.656,2.148,2.283,3.683,2.192,2.353,2.146,2.276,2.126,P ＜ 0.05).There was no statistically significant difference in protecting OAR in 10 cases of esophageal cancer between PLANEUD group and PLANNO_EUD group (t value were 0.408,0.427,0.920,P ＞ 0.05).There was statistically significant difference in protecting OAR in 6 cases of rectum cancer of PLANED group compared with those of PLANNO_EUD group (t values were 2.332,2.693,2.279,2.244,P ＜ 0.05).Conclusion EUD optimization can reduce the doses to OAR which may be quite helpful to reduce the occurrence rate of OAR complications.
