肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
8期
513-515,526
,共4页
陈玲%叶韵斌%陈燕坪%林根%朱伟峰
陳玲%葉韻斌%陳燕坪%林根%硃偉峰
진령%협운빈%진연평%림근%주위봉
肠肿瘤%NF-κB p65%免疫组织化学%k-ras
腸腫瘤%NF-κB p65%免疫組織化學%k-ras
장종류%NF-κB p65%면역조직화학%k-ras
Colorectal cancer%NF-κB p65%lmmunochemistry%k-ras
目的 探讨大肠癌组织中NF-κB p65的活化与k-ras基因突变的相关性.方法 用免疫组织化学方法检测167例已知k-ras基因状态的大肠癌组织中NF-κB p65的核表达.结果 在167例大肠癌组织中,k-ras基因突变59例,突变率35.3 ％;NF-κB p65核表达阳性63例,阳性率37.7％.不同性别、年龄、ECOG评分、病理类型、病理分化程度、TNM分期、淋巴结转移与否的病例k-ras基因突变率和NF-κB p65核表达差异均无统计学意义(均P＞0.05).k-ras基因突变的病例中NF-κB p65核表达率50.8％(30/59),k-ras基因野生型病例中NF-κB p65核表达率30.6％(33/108).两者的表达率差异有统计学意义(P=0.010).结论 大肠癌组织中NF-κB p65的活化与k-ras基因突变相关.
目的 探討大腸癌組織中NF-κB p65的活化與k-ras基因突變的相關性.方法 用免疫組織化學方法檢測167例已知k-ras基因狀態的大腸癌組織中NF-κB p65的覈錶達.結果 在167例大腸癌組織中,k-ras基因突變59例,突變率35.3 ％;NF-κB p65覈錶達暘性63例,暘性率37.7％.不同性彆、年齡、ECOG評分、病理類型、病理分化程度、TNM分期、淋巴結轉移與否的病例k-ras基因突變率和NF-κB p65覈錶達差異均無統計學意義(均P＞0.05).k-ras基因突變的病例中NF-κB p65覈錶達率50.8％(30/59),k-ras基因野生型病例中NF-κB p65覈錶達率30.6％(33/108).兩者的錶達率差異有統計學意義(P=0.010).結論 大腸癌組織中NF-κB p65的活化與k-ras基因突變相關.
목적 탐토대장암조직중NF-κB p65적활화여k-ras기인돌변적상관성.방법 용면역조직화학방법검측167례이지k-ras기인상태적대장암조직중NF-κB p65적핵표체.결과 재167례대장암조직중,k-ras기인돌변59례,돌변솔35.3 ％;NF-κB p65핵표체양성63례,양성솔37.7％.불동성별、년령、ECOG평분、병리류형、병리분화정도、TNM분기、림파결전이여부적병례k-ras기인돌변솔화NF-κB p65핵표체차이균무통계학의의(균P＞0.05).k-ras기인돌변적병례중NF-κB p65핵표체솔50.8％(30/59),k-ras기인야생형병례중NF-κB p65핵표체솔30.6％(33/108).량자적표체솔차이유통계학의의(P=0.010).결론 대장암조직중NF-κB p65적활화여k-ras기인돌변상관.
Objective To investigate the corresponds between NF-κB p65 activation and k-ras mutations.Methods NF-κB p65 activation was analyzed by immunochemistry in 167 colorectal cancer specimens in which the k-ras mutation status was confirmed.Resluts Among 167 colorectal cancer specimens screened,59 (35.3 ％) had k-ras mutations and 63 (37.7 ％) had NF-κB p65 activation.k-ras mutations and NF-κB p65 nuclear expression were no significant difference in different sex,age,ECOG score,pathological types,degrees of pathological differentiation,TNM stage,and metastases on lymph nodes (P＞ 0.05).The positive nuclear expression rate of NF-κB p65 was 50.8 ％ (30/59) in specimens with k-ras mutations and 30.6 ％ (33/108) in specimens with wild type k-ras.There was obviously statistical difference between them (P =0.010).Conclusion NF-κB p65 activation in coloretal cancer was associated with k-ras mutations.
