肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
8期
535-538
,共4页
周丽娜%谭悦%徐燕%计张奕%陈敏斌%王李强
週麗娜%譚悅%徐燕%計張奕%陳敏斌%王李彊
주려나%담열%서연%계장혁%진민빈%왕리강
CYP1A1%基因多态性%结直肠肿瘤%Meta分析
CYP1A1%基因多態性%結直腸腫瘤%Meta分析
CYP1A1%기인다태성%결직장종류%Meta분석
CYP1A1%Polymorphisms%Colorectal neoplasms%Meta-analysis
目的 探讨CYP1A12454A＞G多态性与结直肠癌易感性的关系.方法 通过检索PubMcd、Embase和Web of Science databases数据库,对有关CYP1A1基因多态性与结直肠癌易感性关系的英文文献,用STATA 10.0软件进行Meta分析.结果 共纳入文献15篇,包括6768例患者和7973个对照,CYP1A1 2454A＞G与结直肠癌易感性显著相关(G比A:OR=1.19,95％CI=1.03 ～ 1.37;GG比AA:OR=1.40,95％CI=1.12 ～ 1.75;GG比AG+AA:OR=1.43,95％CI=1.15～1.78).结论 CYP1A12454A＞G基因多态可能与结直肠癌易感性有关.
目的 探討CYP1A12454A＞G多態性與結直腸癌易感性的關繫.方法 通過檢索PubMcd、Embase和Web of Science databases數據庫,對有關CYP1A1基因多態性與結直腸癌易感性關繫的英文文獻,用STATA 10.0軟件進行Meta分析.結果 共納入文獻15篇,包括6768例患者和7973箇對照,CYP1A1 2454A＞G與結直腸癌易感性顯著相關(G比A:OR=1.19,95％CI=1.03 ～ 1.37;GG比AA:OR=1.40,95％CI=1.12 ～ 1.75;GG比AG+AA:OR=1.43,95％CI=1.15～1.78).結論 CYP1A12454A＞G基因多態可能與結直腸癌易感性有關.
목적 탐토CYP1A12454A＞G다태성여결직장암역감성적관계.방법 통과검색PubMcd、Embase화Web of Science databases수거고,대유관CYP1A1기인다태성여결직장암역감성관계적영문문헌,용STATA 10.0연건진행Meta분석.결과 공납입문헌15편,포괄6768례환자화7973개대조,CYP1A1 2454A＞G여결직장암역감성현저상관(G비A:OR=1.19,95％CI=1.03 ～ 1.37;GG비AA:OR=1.40,95％CI=1.12 ～ 1.75;GG비AG+AA:OR=1.43,95％CI=1.15～1.78).결론 CYP1A12454A＞G기인다태가능여결직장암역감성유관.
Objective To evaluate the association between CYP1A1 polymorphism and colorectal cancer risk.Methods PubMed,Embase and Web of Science databases were searched using the search terms as ‘Cytochrome P4501Al’,‘CYP1A1’,‘polymorphism’ and ‘colorectal cancer’.A meta-analysis was performed by STATA 10.0 software to assess the data included.Results By using 6768 cases and 7973 controls from 15 studies,significantly elevated colorectal cancer risks were associated with CYP1A1 2454A＞G in the following models (G vs A:pooled OR =1.19,95 ％ CI =1.03-1.37; GG vs AA:OR =1.40,95 ％ CI =1.12-1.75; GG vs AG+AA:OR =1.43,95 ％ CI =1.15-1.78).Conclusion CYP1A1 2454A＞G may cause an increased risk of colorectal cancer.
