肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
9期
591-594
,共4页
胃肿瘤%半乳糖血凝素-3%预后%免疫组织化学
胃腫瘤%半乳糖血凝素-3%預後%免疫組織化學
위종류%반유당혈응소-3%예후%면역조직화학
Gastric neoplasma%Galectin-3%Prognosis%Immunohistochemistry
目的 研究半乳糖血凝素-3(Gal-3)在胃癌组织中的表达水平,探讨其临床意义.方法 利用Elivison免疫组织化学法检测52例胃癌、21例胃不典型增生,33例胃炎组织中Gal-3的表达水平,比较在胃癌、胃不典型增生、胃炎中Gal-3的表达差异,并探讨其与胃癌临床病理学参数的关系及其临床意义.结果 在胃癌组织、胃不典型增生和胃炎组织中Gal-3表达阳性率分别为94.2％(49/52)、80.0％(16/20)和33.3％(11/30).Gal-3在胃癌中表达阳性率均明显高于胃不典型增生和胃炎(Z值分别为2.181、6.160、3.611,均P＜0.05)；Gal-3在有淋巴结转移、中低分化胃癌组织中的表达率分别为100％(22/22)、100％(45/45),Gal-3在无淋巴结转移、高分化的胃癌组织中的表达分别为78.6％(27/30)、57.1％(4/7).Gal-3在有淋巴结转移、中低分化胃癌组织中的表达显著高于无淋巴结转移、高分化的胃癌(Z=12.463、Z=3.245,均P＜0.05).结论 Gal-3在胃癌组织中的表达阳性率和表达强度显著高于胃不典型增生和胃炎,提示这些蛋白可能在胃癌的发病过程中起一定作用；Gal-3在胃癌中的高表达与淋巴结转移及分化程度相关,可能成为胃癌的预后指标.
目的 研究半乳糖血凝素-3(Gal-3)在胃癌組織中的錶達水平,探討其臨床意義.方法 利用Elivison免疫組織化學法檢測52例胃癌、21例胃不典型增生,33例胃炎組織中Gal-3的錶達水平,比較在胃癌、胃不典型增生、胃炎中Gal-3的錶達差異,併探討其與胃癌臨床病理學參數的關繫及其臨床意義.結果 在胃癌組織、胃不典型增生和胃炎組織中Gal-3錶達暘性率分彆為94.2％(49/52)、80.0％(16/20)和33.3％(11/30).Gal-3在胃癌中錶達暘性率均明顯高于胃不典型增生和胃炎(Z值分彆為2.181、6.160、3.611,均P＜0.05)；Gal-3在有淋巴結轉移、中低分化胃癌組織中的錶達率分彆為100％(22/22)、100％(45/45),Gal-3在無淋巴結轉移、高分化的胃癌組織中的錶達分彆為78.6％(27/30)、57.1％(4/7).Gal-3在有淋巴結轉移、中低分化胃癌組織中的錶達顯著高于無淋巴結轉移、高分化的胃癌(Z=12.463、Z=3.245,均P＜0.05).結論 Gal-3在胃癌組織中的錶達暘性率和錶達彊度顯著高于胃不典型增生和胃炎,提示這些蛋白可能在胃癌的髮病過程中起一定作用；Gal-3在胃癌中的高錶達與淋巴結轉移及分化程度相關,可能成為胃癌的預後指標.
목적 연구반유당혈응소-3(Gal-3)재위암조직중적표체수평,탐토기림상의의.방법 이용Elivison면역조직화학법검측52례위암、21례위불전형증생,33례위염조직중Gal-3적표체수평,비교재위암、위불전형증생、위염중Gal-3적표체차이,병탐토기여위암림상병이학삼수적관계급기림상의의.결과 재위암조직、위불전형증생화위염조직중Gal-3표체양성솔분별위94.2％(49/52)、80.0％(16/20)화33.3％(11/30).Gal-3재위암중표체양성솔균명현고우위불전형증생화위염(Z치분별위2.181、6.160、3.611,균P＜0.05)；Gal-3재유림파결전이、중저분화위암조직중적표체솔분별위100％(22/22)、100％(45/45),Gal-3재무림파결전이、고분화적위암조직중적표체분별위78.6％(27/30)、57.1％(4/7).Gal-3재유림파결전이、중저분화위암조직중적표체현저고우무림파결전이、고분화적위암(Z=12.463、Z=3.245,균P＜0.05).결론 Gal-3재위암조직중적표체양성솔화표체강도현저고우위불전형증생화위염,제시저사단백가능재위암적발병과정중기일정작용；Gal-3재위암중적고표체여림파결전이급분화정도상관,가능성위위암적예후지표.
Objective To explore the expression of galectin-3 in human gastric carcinoma tissues and to investigate its clinincal significances.Methods Immunohistochemistry method was used to detect the expression of galectin-3 in 52 pairs of specimens of gastric carcinoma tissues,33 atypical hypcrplasia of gastric tissues and 20 gastritis tissues.Expression levels of galectin-3 in different tissues were compared and analyzed.The relationship between expression levels and clinical parameters was investigated.Results The positive rates of galectin-3 were 94.2 ％ (49/52),80.0 ％ (16/20) and 33.3 ％ (11/30).The positive rates of galectin-3 were higher in gastric carcinoma than those in atypical hyperplasia and gastritis (Z =2.181,6.160,3.611,all P ＜ 0.05).The expression levels of galectin-3 in lymph node metastasis gastric carcinoma,poorly differentiated gastric carcinoma were 100 ％ (22/22),100 ％ (45/45) respectively.Galectin-3 expression in patients without lymph node metastasis,high differentiation in gastric carcinoma were 78.6 ％ (27/30),57.1％ (4/7)respectively.The expression levels of galectin-3 were correlated with metastasis and differentiation,with higher expressions in the cases with metastatic lymph nodes (Z =12.463,P ＜ 0.05) and in poor differentiation tissues (Z =3.245,P ＜ 0.05).Conclusion Galectin-3 is overexpressed in gastric carcinoma tissues,indicating that both of them may play roles in the pathogenesis of gastric carcinoma.The overexpression of galectin-3 is correlated with metastatic lymph nodes and poor differentiation,indicating that galectin-3 may be prognostic indicator of gastric carcinoma.
