肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
9期
605-608
,共4页
郑亚琴%任俊丽%褚薛刚%郑旭亮%孟慧敏%邢晓汾
鄭亞琴%任俊麗%褚薛剛%鄭旭亮%孟慧敏%邢曉汾
정아금%임준려%저설강%정욱량%맹혜민%형효분
直肠肿瘤%快速旋转调强放疗%放射疗法,调强适形%放射治疗剂量
直腸腫瘤%快速鏇轉調彊放療%放射療法,調彊適形%放射治療劑量
직장종류%쾌속선전조강방료%방사요법,조강괄형%방사치료제량
Rectal neoplasms%RapidArc%Radiotherapy,intensity-modulated%Radiotherapy dosage
目的 探讨快速旋转调强(RapidArc)技术在直肠癌术后放疗的可行性及潜在优势.方法 选择8例直肠癌术后患者,处方剂量为50Gy,2 Gy/次,5次/周.用治疗计划系统分别进行固定野动态调强放疗(IMRT)计划和RapidArc计划设计,比较两组计划的靶区适形度指数、均匀性指数、危及器官的受照剂量体积、两组计划实施时的治疗时间和机器跳数.结果 RapidArc计划的适形指数(0.89±0.02)优于五野(5F)-IMRT计划的适形指数(0.87±0.02)(t=3.286,P＜0.05),RapidArc计划靶区的均匀性指数(1.060±0.005)及平均剂量[(52.55 ±0.76)Gy]略低于5F-IMRT计划的均匀性指数(1.064±0.007)及平均剂量[(52.90±0.82) Gy](t值分别为-1.459、-1.000,P＞0.05),RapidArc计划膀胱、小肠在高剂量区受量及平均剂量较5F-IMRT计划低,骨髓的受量RapidArc计划低于5F-IMRT计划,差异有统计学意义(P＜0.05).RapidArc计划和5F-IMRT的机器跳数分别为(631±68)MU、(1046±146)MU,差异有统计学意义(t=-5.830,P=0.001),治疗时间分别为(78±5)s、(348±29)s,差异有统计学意义(t=-26.358,P＜0.05).结论 RapidArc计划较5F-IMRT计划提高了靶区的适形度,减少了危及器官高剂量区的受照剂量,降低了机器跳数,缩短了治疗时间,提高了患者的舒适性和治疗的效率.
目的 探討快速鏇轉調彊(RapidArc)技術在直腸癌術後放療的可行性及潛在優勢.方法 選擇8例直腸癌術後患者,處方劑量為50Gy,2 Gy/次,5次/週.用治療計劃繫統分彆進行固定野動態調彊放療(IMRT)計劃和RapidArc計劃設計,比較兩組計劃的靶區適形度指數、均勻性指數、危及器官的受照劑量體積、兩組計劃實施時的治療時間和機器跳數.結果 RapidArc計劃的適形指數(0.89±0.02)優于五野(5F)-IMRT計劃的適形指數(0.87±0.02)(t=3.286,P＜0.05),RapidArc計劃靶區的均勻性指數(1.060±0.005)及平均劑量[(52.55 ±0.76)Gy]略低于5F-IMRT計劃的均勻性指數(1.064±0.007)及平均劑量[(52.90±0.82) Gy](t值分彆為-1.459、-1.000,P＞0.05),RapidArc計劃膀胱、小腸在高劑量區受量及平均劑量較5F-IMRT計劃低,骨髓的受量RapidArc計劃低于5F-IMRT計劃,差異有統計學意義(P＜0.05).RapidArc計劃和5F-IMRT的機器跳數分彆為(631±68)MU、(1046±146)MU,差異有統計學意義(t=-5.830,P=0.001),治療時間分彆為(78±5)s、(348±29)s,差異有統計學意義(t=-26.358,P＜0.05).結論 RapidArc計劃較5F-IMRT計劃提高瞭靶區的適形度,減少瞭危及器官高劑量區的受照劑量,降低瞭機器跳數,縮短瞭治療時間,提高瞭患者的舒適性和治療的效率.
목적 탐토쾌속선전조강(RapidArc)기술재직장암술후방료적가행성급잠재우세.방법 선택8례직장암술후환자,처방제량위50Gy,2 Gy/차,5차/주.용치료계화계통분별진행고정야동태조강방료(IMRT)계화화RapidArc계화설계,비교량조계화적파구괄형도지수、균균성지수、위급기관적수조제량체적、량조계화실시시적치료시간화궤기도수.결과 RapidArc계화적괄형지수(0.89±0.02)우우오야(5F)-IMRT계화적괄형지수(0.87±0.02)(t=3.286,P＜0.05),RapidArc계화파구적균균성지수(1.060±0.005)급평균제량[(52.55 ±0.76)Gy]략저우5F-IMRT계화적균균성지수(1.064±0.007)급평균제량[(52.90±0.82) Gy](t치분별위-1.459、-1.000,P＞0.05),RapidArc계화방광、소장재고제량구수량급평균제량교5F-IMRT계화저,골수적수량RapidArc계화저우5F-IMRT계화,차이유통계학의의(P＜0.05).RapidArc계화화5F-IMRT적궤기도수분별위(631±68)MU、(1046±146)MU,차이유통계학의의(t=-5.830,P=0.001),치료시간분별위(78±5)s、(348±29)s,차이유통계학의의(t=-26.358,P＜0.05).결론 RapidArc계화교5F-IMRT계화제고료파구적괄형도,감소료위급기관고제량구적수조제량,강저료궤기도수,축단료치료시간,제고료환자적서괄성화치료적효솔.
Objective To investigate the feasibility and potential advantages of RapidArc applied to the radiotherapy of the postoperative rectal cancer.Methods 8 postoperative patients with rectal cancer were selected to be treated with a dose of 50Gy in fraction of 2Gy every time and 5 times a week.IMRT and RapidArc were used respectively to compare different target conformities,homogeneity index,dose-volume histogram data,treatment times and monitor units.Results The conformal index by RapidArc was 0.89±0.02 which was better than those by 5F-IMRT,0.87±0.02 (t =3.286,P ＜ 0.05),while the homogeneity index of target volume (1.060±0.005) and average dose [(52.55±0.76) Gy] by RapidArc were a little less than the homogeneity index of target volume (1.064±0.007) and average dose [(52.90±0.82) Gy] by 5F-IMRT (t =-1.459,-1.000,P ＞ 0.05).The exposure dose and mean dose of bladder and small bowel in high dose region by RapidArc were lower than those by 5F-IMRT,as well as bone marrow.The differences were statistical significant (P ＜ 0.05).The monitor units by RapidArc and by 5F-IMRT were (631±68) MU and (1046±146) MU,respectively (t =-5.830,P ＜ 0.05),while the mean treatment times were (78±5) s and (348±29) s,respectively (t =-26.358,P ＜ 0.05).Conclusion Compared with 5F-IMRT,RapidArc improves the target conformities and lowers the exposure dose for the organs at risk in high dose region while using fewer monitor units and less treatment time,which helps comforting patients and improving the efficiency.
