CAJ | 학술논문

近年来,与肺癌复发转移相关微小RNA (miRNA)的临床研究取得了重要进展.在PubMed上检索与非小细胞肺癌(NSCLC)术后复发转移相关的miRNA临床研究文献,结果发现miRNA 在肺癌中具有差异性表达,部分已揭示与术后复发转移预后相关,可以作为今后的治疗靶点.但目前临床研究中发现的与NSCLC术后复发转移相关的miRNA,绝大部分尚处在筛选阶段,缺少大样本的临床验证,尤其是随机、对照研究.
근년래,여폐암복발전이상관미소RNA (miRNA)적림상연구취득료중요진전.재PubMed상검색여비소세포폐암(NSCLC)술후복발전이상관적miRNA림상연구문헌,결과발현miRNA 재폐암중구유차이성표체,부분이게시여술후복발전이예후상관,가이작위금후적치료파점.단목전림상연구중발현적여NSCLC술후복발전이상관적miRNA,절대부분상처재사선계단,결소대양본적림상험증,우기시수궤、대조연구.
microRNAs (miRNAs) related to the recurrence and metastasis of non-small-cell lung cancer (NSCLC) in recent years have made important progress.The authors search the clinical researches related to the link between the miRNA and the recurrence and metastasis of postoperative NSCLC on PubMed.The clinical studies produced contradictory data.miRNA differentially expressed in lung cancer based on their data.Some but not all suggested that the miRNA is associated with the metastasis and recurrence of NSCLC,suggesting the miRNA could be a potential therapeutic targets for therapy of lung cancers.However,most studies are still at the screening stage,which is lack of a large group of patients,especially in random,controlled study to verify the miRNA predict recurrence transfer orientation or prognosis,which can be the direction for the practice of clinical trials in the future.