肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
11期
726-729
,共4页
马秋双%张金库%周炳娟%赵文明%赵亚飞%孙吉瑞%李金梅%乔海芝%张丙信
馬鞦雙%張金庫%週炳娟%趙文明%趙亞飛%孫吉瑞%李金梅%喬海芝%張丙信
마추쌍%장금고%주병연%조문명%조아비%손길서%리금매%교해지%장병신
乳腺肿瘤%原癌基因蛋白质类%FoxM1%c-myc%基底细胞样,肿瘤
乳腺腫瘤%原癌基因蛋白質類%FoxM1%c-myc%基底細胞樣,腫瘤
유선종류%원암기인단백질류%FoxM1%c-myc%기저세포양,종류
Breast neoplasms%Proto-oncogene proteins%FoxM1%c-myc%Basal cell like,neoplasms
目的 探讨FoxM1和c-myc蛋白在基底细胞样型乳腺癌(BLBC)、非基底细胞样型乳腺癌(non-BLBC)及癌旁正常乳腺组织中的表达情况及二者之间的相互关系.方法 采用免疫组织化学法检测66例BLBC及其癌旁正常乳腺组织、70例non-BLBC组织FoxM1和c-myc蛋白的表达情况,采用Spearman相关分析法分析其与病理临床特征的关系.结果 BLBC、non-BLBC及癌旁正常乳腺组织中FoxM1蛋白阳性表达率分别为77.3％(51/66)、60.0％(42/70)和13.6％(9/66),c-myc蛋白阳性表达率分别为71.2％(47/66)、54.3％(38/70)和22.7％(15/66),FoxM1和c-myc蛋白在BLBC和non-BLBC组织中表达率均明显高于癌旁正常乳腺组织,且在BLBC组织中的表达明显高于non-BLBC组织,差异均有统计学意义(均P＜ 0.05).在BLBC中FoxM1和c-myc蛋白表达呈正相关(r=0.294,P＜ 0.05),且FoxM1和c-myc蛋白的表达与BLBC淋巴结转移及临床分期有关(P＜0.05).结论 FoxM1和c-myc蛋白参与了BLBC的发生、发展,并且FoxM1和c-myc蛋白有一定的协同作用.
目的 探討FoxM1和c-myc蛋白在基底細胞樣型乳腺癌(BLBC)、非基底細胞樣型乳腺癌(non-BLBC)及癌徬正常乳腺組織中的錶達情況及二者之間的相互關繫.方法 採用免疫組織化學法檢測66例BLBC及其癌徬正常乳腺組織、70例non-BLBC組織FoxM1和c-myc蛋白的錶達情況,採用Spearman相關分析法分析其與病理臨床特徵的關繫.結果 BLBC、non-BLBC及癌徬正常乳腺組織中FoxM1蛋白暘性錶達率分彆為77.3％(51/66)、60.0％(42/70)和13.6％(9/66),c-myc蛋白暘性錶達率分彆為71.2％(47/66)、54.3％(38/70)和22.7％(15/66),FoxM1和c-myc蛋白在BLBC和non-BLBC組織中錶達率均明顯高于癌徬正常乳腺組織,且在BLBC組織中的錶達明顯高于non-BLBC組織,差異均有統計學意義(均P＜ 0.05).在BLBC中FoxM1和c-myc蛋白錶達呈正相關(r=0.294,P＜ 0.05),且FoxM1和c-myc蛋白的錶達與BLBC淋巴結轉移及臨床分期有關(P＜0.05).結論 FoxM1和c-myc蛋白參與瞭BLBC的髮生、髮展,併且FoxM1和c-myc蛋白有一定的協同作用.
목적 탐토FoxM1화c-myc단백재기저세포양형유선암(BLBC)、비기저세포양형유선암(non-BLBC)급암방정상유선조직중적표체정황급이자지간적상호관계.방법 채용면역조직화학법검측66례BLBC급기암방정상유선조직、70례non-BLBC조직FoxM1화c-myc단백적표체정황,채용Spearman상관분석법분석기여병리림상특정적관계.결과 BLBC、non-BLBC급암방정상유선조직중FoxM1단백양성표체솔분별위77.3％(51/66)、60.0％(42/70)화13.6％(9/66),c-myc단백양성표체솔분별위71.2％(47/66)、54.3％(38/70)화22.7％(15/66),FoxM1화c-myc단백재BLBC화non-BLBC조직중표체솔균명현고우암방정상유선조직,차재BLBC조직중적표체명현고우non-BLBC조직,차이균유통계학의의(균P＜ 0.05).재BLBC중FoxM1화c-myc단백표체정정상관(r=0.294,P＜ 0.05),차FoxM1화c-myc단백적표체여BLBC림파결전이급림상분기유관(P＜0.05).결론 FoxM1화c-myc단백삼여료BLBC적발생、발전,병차FoxM1화c-myc단백유일정적협동작용.
Objective To detect the protein expressions of FoxM1 and c-myc in basal-like breast carcinoma and explore their correlation.Methods The expression of FoxM1 and c-myc was detected in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal adjacent breast tissue by immunohistochemistry.The relationship of them was analyzed.Rusults The expression rates of FoxM1 and c-myc protein in BLBC [77.3 ％ (51/66),71.2 ％ (47/66)] was significant increased than that in normal breast tissue [13.6 ％ (9/66),22.7 ％ (15/66)],and higher than that in non-BLBC [60.0 ％ (42/70),54.3 ％ (38/70)].The expression of FoxM1 and c-myc positively correlated with lymph nodes metastasis and TNM staging of BLBC (P ＜ 0.05).Positive expressions correlation could be found between the expression of FoxM1 and that of c-myc as well (r =0.294,P ＜ 0.05).Conclusion FoxM1 and c-myc may play important roles in the carcinogenesis and development of BLBC and the study supports the positive feedback effect between the expressions of FoxM1 and c-myc furthermore.
