肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
12期
812-815
,共4页
癌,导管,乳腺%癌,乳头状%标记,生物学%乳头溢液
癌,導管,乳腺%癌,乳頭狀%標記,生物學%乳頭溢液
암,도관,유선%암,유두상%표기,생물학%유두일액
Carcinoma,ductal,breast%Carcinoma,papillary%Tumor markers,biological%Nipple discharge
目的 探讨乳头溢液糖类抗原153(CA153)、癌胚抗原(CEA)及糖类抗原125(CA125)联合检测在乳腺导管内乳头状病变诊断中的价值.方法 检测154例乳腺导管内乳头状病变患者(恶性组58例,良性组96例)乳头溢液中CA153、CEA及CA125的水平,分析其诊断价值及其与临床病理因素的关系,另选30例妊娠健康妇女乳头溢液作对照.结果 恶性组乳头溢液中CA153、CEA及CA125水平[(130.11±29.62)U/ml、(89.23±28.94) ng/ml、(41.29±16,61)U/ml]显著高于良性组和健康组(P＜0.01);与良性组和健康组比较,恶性组溢液中CA153、CEA、CA125单项检测阳性率(62.07％、46.55％、55.17％)及联合检测阳性率(82.76％)均明显增高(P＜0.05);恶性组乳头溢液联合检测阳性率显著高于单项检查(P＜0.01).乳头溢液及血清三项联合检测可提高敏感性(96.55％)和阴性预测值(97.30％).溢液CA153、CEA、CA125水平在患者年龄、部位、肿瘤大小、溢液性状不同组间差异无统计学意义(P＞0.05);溢液CA153、CEA水平在雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(Her-2)、缺氧诱导因子-1α(HIF-1 α)及淋巴结转移不同组差异有统计学意义(P＜0.05);CA125在HIF-1 α、Ki-67不同组间差异有统计学意义(P＜ 0.05);CA125在ER& PR、Her-2不同组间,CA153水平在Ki-67不同组间差异无统计学意义(P＞0.05).结论 乳头溢液及血清CA153、CEA及CA125联合检测有互补性,能弥补单项检测临床应用的不足,对提高乳腺导管内乳头状癌诊断的敏感性和阴性预测值有一定意义.
目的 探討乳頭溢液糖類抗原153(CA153)、癌胚抗原(CEA)及糖類抗原125(CA125)聯閤檢測在乳腺導管內乳頭狀病變診斷中的價值.方法 檢測154例乳腺導管內乳頭狀病變患者(噁性組58例,良性組96例)乳頭溢液中CA153、CEA及CA125的水平,分析其診斷價值及其與臨床病理因素的關繫,另選30例妊娠健康婦女乳頭溢液作對照.結果 噁性組乳頭溢液中CA153、CEA及CA125水平[(130.11±29.62)U/ml、(89.23±28.94) ng/ml、(41.29±16,61)U/ml]顯著高于良性組和健康組(P＜0.01);與良性組和健康組比較,噁性組溢液中CA153、CEA、CA125單項檢測暘性率(62.07％、46.55％、55.17％)及聯閤檢測暘性率(82.76％)均明顯增高(P＜0.05);噁性組乳頭溢液聯閤檢測暘性率顯著高于單項檢查(P＜0.01).乳頭溢液及血清三項聯閤檢測可提高敏感性(96.55％)和陰性預測值(97.30％).溢液CA153、CEA、CA125水平在患者年齡、部位、腫瘤大小、溢液性狀不同組間差異無統計學意義(P＞0.05);溢液CA153、CEA水平在雌激素受體(ER)、孕激素受體(PR)、人類錶皮生長因子受體-2(Her-2)、缺氧誘導因子-1α(HIF-1 α)及淋巴結轉移不同組差異有統計學意義(P＜0.05);CA125在HIF-1 α、Ki-67不同組間差異有統計學意義(P＜ 0.05);CA125在ER& PR、Her-2不同組間,CA153水平在Ki-67不同組間差異無統計學意義(P＞0.05).結論 乳頭溢液及血清CA153、CEA及CA125聯閤檢測有互補性,能瀰補單項檢測臨床應用的不足,對提高乳腺導管內乳頭狀癌診斷的敏感性和陰性預測值有一定意義.
목적 탐토유두일액당류항원153(CA153)、암배항원(CEA)급당류항원125(CA125)연합검측재유선도관내유두상병변진단중적개치.방법 검측154례유선도관내유두상병변환자(악성조58례,량성조96례)유두일액중CA153、CEA급CA125적수평,분석기진단개치급기여림상병리인소적관계,령선30례임신건강부녀유두일액작대조.결과 악성조유두일액중CA153、CEA급CA125수평[(130.11±29.62)U/ml、(89.23±28.94) ng/ml、(41.29±16,61)U/ml]현저고우량성조화건강조(P＜0.01);여량성조화건강조비교,악성조일액중CA153、CEA、CA125단항검측양성솔(62.07％、46.55％、55.17％)급연합검측양성솔(82.76％)균명현증고(P＜0.05);악성조유두일액연합검측양성솔현저고우단항검사(P＜0.01).유두일액급혈청삼항연합검측가제고민감성(96.55％)화음성예측치(97.30％).일액CA153、CEA、CA125수평재환자년령、부위、종류대소、일액성상불동조간차이무통계학의의(P＞0.05);일액CA153、CEA수평재자격소수체(ER)、잉격소수체(PR)、인류표피생장인자수체-2(Her-2)、결양유도인자-1α(HIF-1 α)급림파결전이불동조차이유통계학의의(P＜0.05);CA125재HIF-1 α、Ki-67불동조간차이유통계학의의(P＜ 0.05);CA125재ER& PR、Her-2불동조간,CA153수평재Ki-67불동조간차이무통계학의의(P＞0.05).결론 유두일액급혈청CA153、CEA급CA125연합검측유호보성,능미보단항검측림상응용적불족,대제고유선도관내유두상암진단적민감성화음성예측치유일정의의.
Objective To study the value of tumor markers of CA153,CEA and CA125 in nipple discharge of breast intraductal papillary leision on detection of breast carcinoma.Methods 154 cases of breast intraductal papillary leision with nipple discharge were studied.Among them there were 58 cases with breast intraductal papillary carcinoma and 96 cases with intraductal papilloma.The nipple discharged and serum from the 154 cases were collected and CA153,CEA and CA125 levels were measured both in nipple discharge and serum with electrochemiluminescence method,and were compared with the results of ER,PR,HIF-1α and Ki-67 detected by SP method in breast tissue.Results The CA153,CEA and CA125 levels of nipple discharge in intraductal papillary carcinoma [(130.1 1±29.62) U/ml,(89.23±28.94) ng/ml,(41.29±16.61) U/ml]were significantly higher than those of the contrast groups,and had a positive correlation with the Ki-67,HIF-1αand lymphnode metastas (P ＜ 0.05),and negative correlation with the level of ER,PR and Her-2 (P ＜ 0.05).The positive rate of CA153,CEA or CA125 in nipple discharge (62.07 ％,46.55 ％,55.17 ％) were significantly higher than that in serum (P ＜ 0.05).The sensitivity of the combined detection of the three tumor markes both in discharge and serum was 96.55 ％,and the negative predictive value was 97.30 ％,which were significantly higher than that in other detection (P ＜ 0.05).Conclusions The positive rate of CA153,CEA and CA125 in nipple discharge were significantly higher than that in serum.The dynamic combined detection of CA153,CEA and CA125 both in nipple discharge and in serum could increase the diagnosis rate of breast intraductal papillary carcinoma.
