CAJ | 학술논문

目的探讨膀胱癌组织中乳腺癌扩增基因1(AIB1)基因的表达及其临床意义.方法收集30例因膀胱癌行全膀胱切除术或经尿道膀胱癌电切术的标本,术前病理检查均为尿路上皮癌,采用免疫组织化学方法检测膀胱癌组织和癌旁组织中AIB1的表达情况.结果膀胱癌组织AIB1的阳性表达率高于癌旁组织[43.3％(13/30)比3.3％(1/30),x2=4.316,p＜0.05],高分期膀胱癌组织AIB1的阳性表达率高于低分期膀胱癌组织[T1、T2、L期分别为25.0％(2/8)、42.9％(6/14)、62.5％(5/8),x2=4.623,P＜0.05].AIB1的表达与患者性别、年龄、肿瘤数目和病理分级无明显相关性(均P＞0.05).结论 AIB1与膀胱癌关系密切,有可能成为判断膀胱癌预后的重要指标.
목적 탐토방광암조직중유선암확증기인1(AIB1)기인적표체급기림상의의.방법 수집30례인방광암행전방광절제술혹경뇨도방광암전절술적표본,술전병리검사균위뇨로상피암,채용면역조직화학방법검측방광암조직화암방조직중AIB1적표체정황.결과 방광암조직AIB1적양성표체솔고우암방조직[43.3％(13/30)비3.3％(1/30),x2=4.316,p＜0.05],고분기방광암조직AIB1적양성표체솔고우저분기방광암조직[T1、T2、L기분별위25.0％(2/8)、42.9％(6/14)、62.5％(5/8),x2=4.623,P＜0.05].AIB1적표체여환자성별、년령、종류수목화병리분급무명현상관성(균P＞0.05).결론 AIB1여방광암관계밀절,유가능성위판단방광암예후적중요지표.
Objective To investigate the expression of AIB1 protein in bladder cancer and its significance.Methods 30 cases of bladder cancer and 30 adjacent normal tissues were collected from 30 patients underwent radical or TURBt.The level of AIB1 protein expressed in these tissues were detected by immunohitochemical method.Results The positive rate of AIB1 protein in bladder carcinoma was higher than that in the normal tissues [43.3 ％ (13/30) vs 3.3 ％ (1/30),x2 =4.316,P ＜ 0.05].The positive rate of AIB1 in T3 stage was higher than that in T1 or T2 stage [62.5 ％ (5/8) vs 25.0 ％ (2/8),42.9 ％ (6/14),x2 =4.623,P ＜ 0.05].No correlation was found between the expression of AIB1 protein and the sex,age,multiplicity or pathological grade (P ＞ 0.05).Conclusions There is a close relationship between AIB1 and bladder cancer.AIB1 might have great value on the prognosis of patients with bladder cancer.