肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2013年
12期
856-858
,共3页
胰腺肿瘤%Wnt/ β-catenin信号通路%细胞周期%细胞凋亡%肿瘤干细胞%血管生成
胰腺腫瘤%Wnt/ β-catenin信號通路%細胞週期%細胞凋亡%腫瘤榦細胞%血管生成
이선종류%Wnt/ β-catenin신호통로%세포주기%세포조망%종류간세포%혈관생성
Pancreatic neoplasms%Wnt/β-catenin signaling pathway%Cell cycle%Apoptosis%Tumor stem cells%Angiogenesis
Wnt信号通路是调节细胞增殖、分化及移型的经典通路之一.Wnt蛋白可与多种不同Wnt蛋白受体结合,激活细胞内不同的信号通路,研究证实Wnt/β-catenin信号通路与胰腺癌的发生发展密切相关.对Wnt/β-catenin信号通路在细胞周期、细胞凋亡、肿瘤干细胞及血管生成方面对胰腺癌发生发展的影响进行综述.
Wnt信號通路是調節細胞增殖、分化及移型的經典通路之一.Wnt蛋白可與多種不同Wnt蛋白受體結閤,激活細胞內不同的信號通路,研究證實Wnt/β-catenin信號通路與胰腺癌的髮生髮展密切相關.對Wnt/β-catenin信號通路在細胞週期、細胞凋亡、腫瘤榦細胞及血管生成方麵對胰腺癌髮生髮展的影響進行綜述.
Wnt신호통로시조절세포증식、분화급이형적경전통로지일.Wnt단백가여다충불동Wnt단백수체결합,격활세포내불동적신호통로,연구증실Wnt/β-catenin신호통로여이선암적발생발전밀절상관.대Wnt/β-catenin신호통로재세포주기、세포조망、종류간세포급혈관생성방면대이선암발생발전적영향진행종술.
Wnt signaling pathway is one of canonical pathways that can regulate diverse processes such as cell proliferation,differentiation,migration.Interaction between Wnt ligands and Wnt receptors results in an activation ofdifferent intracellular signaling pathways,and Wnt/β-catenin signaling pathway has been proved to have a close relationship with pancreatic cancer.This review presents a brief overview of Wnt/β-catenin signaling pathway in the mechanism of the tumorigenesis of the pancreatic cancer at deregulation of cell cycle,apoptosis,cancer stem cells and angiogenesis.
