CAJ | 학술논문

目的检测凋亡抑制蛋白Survivin、缺氧诱导因子-1α(HIF-1α)在前列腺增生和前列腺癌组织中的表达,探讨二者在前列腺癌发生、发展中的作用及相互关系.方法免疫组织化学SP法检测Survivin、HIF-1 α在前列腺增生(15例)和前列腺癌(62例)组织中的表达,分析Survivin、HIF-1 α与前列腺癌临床病理特征的关系及二者之间的关系.结果 Survivin、HIF-1 α在62例前列腺癌组织中的阳性表达分别为44例(71.0％)、43例(69.4％),在15例前列腺增生组织中的阳性表达分别为1例(6.7％)、0,两组差异均有统计学意义(x2值分别为20.56、23.56,均P=0.001);Survivin和HIF-1α在前列腺癌组织中表达的阳性率与前列腺癌的组织学分级、临床分期有关(x2值分别为10.64、5.39、7.62、6.43,均P＜0.05),二者表达呈正相关(rs=0.350,P=0.006).结论 Survivin与HIF-1 α在前列腺癌发生、发展中起重要作用,两者之间存在协同作用.
목적 검측조망억제단백Survivin、결양유도인자-1α(HIF-1α)재전렬선증생화전렬선암조직중적표체,탐토이자재전렬선암발생、발전중적작용급상호관계.방법 면역조직화학SP법검측Survivin、HIF-1 α재전렬선증생(15례)화전렬선암(62례)조직중적표체,분석Survivin、HIF-1 α여전렬선암림상병리특정적관계급이자지간적관계.결과 Survivin、HIF-1 α재62례전렬선암조직중적양성표체분별위44례(71.0％)、43례(69.4％),재15례전렬선증생조직중적양성표체분별위1례(6.7％)、0,량조차이균유통계학의의(x2치분별위20.56、23.56,균P=0.001);Survivin화HIF-1α재전렬선암조직중표체적양성솔여전렬선암적조직학분급、림상분기유관(x2치분별위10.64、5.39、7.62、6.43,균P＜0.05),이자표체정정상관(rs=0.350,P=0.006).결론 Survivin여HIF-1 α재전렬선암발생、발전중기중요작용,량자지간존재협동작용.
Objective To detect the expression of Survivin and hypoxia inducible factor-1α (HIF-1α) in prostatic hyperplasia and prostatic carcinoma,and investigate their roles and mutual correlations in pathogenesis and progression of prostatic carcinoma.Methods The expression of Survivin and HIF-1α in proliferative lesions of prostate (15 cases) and prostatic carcinoma (62 cases) were detected by immunohistochemistry method.The relationship between the expressions of Survivin and HIF-1α was analyzed,as well as their correlations with clinicopathological features.Results The positive expression of Survivin and HIF-1α were significantly higher in the prostatic carcinoma [71.0 ％ (44/62) and 69.4 ％ (43/62),respectively] compared with those of the prostatic proliferation [6.7 ％ (1/15) and 0] (x2 =20.56,P 0.001; x2 =23.56,P =0.001,respectively).The expression of Survivin and HIF-1α in prostate carcinoma was significantly related with the histological grading,clinical staging (x2 =10.64,5.39,7.62,6.43,all P ＜ 0.05).And there was positively correlated between Survivin and HIF-lα (rs =0.350,P =0.006).Conclusion Survivin and HIF-1α synergistically play important roles in pathogenesis and progression of prostatic carcinoma.