肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
1期
52-55
,共4页
鼻咽肿瘤%p53蛋白%nm23-H1蛋白%淋巴结转移
鼻嚥腫瘤%p53蛋白%nm23-H1蛋白%淋巴結轉移
비인종류%p53단백%nm23-H1단백%림파결전이
Nasopharyngeal neoplasms%p53 protein%nm23-H1 protein%Lymph node metastasis
目的 探讨p53和nm23-H1蛋白在鼻咽癌中的表达及其与临床的相关性.方法 应用免疫组织化学方法对鼻咽癌40例、慢性鼻咽炎22例组织中p53和nm23-H1蛋白的表达进行检测,同时与临床相关资料进行对比研究.结果 慢性鼻咽炎组p53及nm23-H1蛋白的阳性率分别为1.0％、27.2％,而鼻咽癌组为92.5％、55.0％.在nm23-H1蛋白表达阳性的22例鼻咽癌组织中p53阳性表达9例(40.9％),在nm23-H1表达阴性的18例中p53蛋白阳性表达17例(94.4％).鼻咽癌组织中p53和nm23-H1蛋白的表达明显高于慢性鼻咽炎组织.p53蛋白表达与鼻咽癌淋巴结转移、临床分期和病理学分级呈正相关,与肿瘤T分级无关;nm23-H1蛋白表达与鼻咽癌淋巴结转移及临床分期呈负相关,与肿瘤T分级无关.结论 抑癌基因p53和nm23-H1在鼻咽癌的发生、发展及转移过程中起着协同、调控作用,可成为临床诊断和评价预后的重要生物学标志.
目的 探討p53和nm23-H1蛋白在鼻嚥癌中的錶達及其與臨床的相關性.方法 應用免疫組織化學方法對鼻嚥癌40例、慢性鼻嚥炎22例組織中p53和nm23-H1蛋白的錶達進行檢測,同時與臨床相關資料進行對比研究.結果 慢性鼻嚥炎組p53及nm23-H1蛋白的暘性率分彆為1.0％、27.2％,而鼻嚥癌組為92.5％、55.0％.在nm23-H1蛋白錶達暘性的22例鼻嚥癌組織中p53暘性錶達9例(40.9％),在nm23-H1錶達陰性的18例中p53蛋白暘性錶達17例(94.4％).鼻嚥癌組織中p53和nm23-H1蛋白的錶達明顯高于慢性鼻嚥炎組織.p53蛋白錶達與鼻嚥癌淋巴結轉移、臨床分期和病理學分級呈正相關,與腫瘤T分級無關;nm23-H1蛋白錶達與鼻嚥癌淋巴結轉移及臨床分期呈負相關,與腫瘤T分級無關.結論 抑癌基因p53和nm23-H1在鼻嚥癌的髮生、髮展及轉移過程中起著協同、調控作用,可成為臨床診斷和評價預後的重要生物學標誌.
목적 탐토p53화nm23-H1단백재비인암중적표체급기여림상적상관성.방법 응용면역조직화학방법대비인암40례、만성비인염22례조직중p53화nm23-H1단백적표체진행검측,동시여림상상관자료진행대비연구.결과 만성비인염조p53급nm23-H1단백적양성솔분별위1.0％、27.2％,이비인암조위92.5％、55.0％.재nm23-H1단백표체양성적22례비인암조직중p53양성표체9례(40.9％),재nm23-H1표체음성적18례중p53단백양성표체17례(94.4％).비인암조직중p53화nm23-H1단백적표체명현고우만성비인염조직.p53단백표체여비인암림파결전이、림상분기화병이학분급정정상관,여종류T분급무관;nm23-H1단백표체여비인암림파결전이급림상분기정부상관,여종류T분급무관.결론 억암기인p53화nm23-H1재비인암적발생、발전급전이과정중기착협동、조공작용,가성위림상진단화평개예후적중요생물학표지.
Objective To sdudy the expression of p53 and nm23-H1 proteins and their clinical significance in nasopharyngeal carcinoma.Methods The expression of p53 and nm23-H1 proteins were detected by immunohistochemistry method in 40 cases with nasopharyngeal carcinoma and 22 cases with chronic inflammation of nasopharyngeal mucosa tissues.Results Positive rates of p53 and nm23-H1 in chronic nasopharyngitis group were 1.0 ％,27.2 ％,and in the NPC group were 92.5 ％,55.0 ％.There were 9 cases with the positive expression of p53 in 22 cases of nasopharyngeal carcinoma tissues with the positive expression of nm23-H1 (40.9 ％).There were 17 cases with the positive expression of p53 in 18 cases with the negative expression of nm23-H1 (94.4 ％).The expression of p53 and nm23-H1 proteins in nasopharyngeal carcinoma were much higher than that in chronic inflammation of nasopharyngeal mucosa tissues.The expression of p53 protein in nasopharyngeal carcinoma with metastatic lymph node was higher than that in nasopharyngeal carcinoma without metastatic lymph node,but nm23-H1 protein lower.The expression of p53 protein was positively correlated with the metastasis,clinnical staging and pathological classification but not correlated with T classification of nasopharyngeal carcinoma.The expression of nm23-H1 protein was negative correlation with the metastasis and clinical staging of nasopharyngeal carcinoma.Conclusion p53 and nm23-H1 play important coordinated regulation roles in the carcinogenesis,development and metastasis of nasopharyngeal carcinoma and will probably become the key biological marks in the judging and evaluating prognosis of nasopharyngeal carcinoma.
