肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
2期
129-133
,共5页
肺肿瘤%微小RNA%标志物
肺腫瘤%微小RNA%標誌物
폐종류%미소RNA%표지물
Lung neoplsms%microRNA%Biomarkers
微小RNA(miRNA)的生物学功能广泛而重要,参与发育、生长、死亡等整个生命过程.超过50％的miRNA位于肿瘤相关区域或脆性区域,与肿瘤发生、发展、侵袭转移关系密切的miRNA的发现使人们对基因表达调节有了新认识,也为肺癌等恶性肿瘤侵袭转移机制的研究以及miRNA在诊断治疗中的应用开拓了新视野.文章综述了miRNA在肺癌发病机制中的作用,并探讨其作为肺癌诊断与预后标志物的可能性及作为潜在治疗性靶点的应用前景.
微小RNA(miRNA)的生物學功能廣汎而重要,參與髮育、生長、死亡等整箇生命過程.超過50％的miRNA位于腫瘤相關區域或脆性區域,與腫瘤髮生、髮展、侵襲轉移關繫密切的miRNA的髮現使人們對基因錶達調節有瞭新認識,也為肺癌等噁性腫瘤侵襲轉移機製的研究以及miRNA在診斷治療中的應用開拓瞭新視野.文章綜述瞭miRNA在肺癌髮病機製中的作用,併探討其作為肺癌診斷與預後標誌物的可能性及作為潛在治療性靶點的應用前景.
미소RNA(miRNA)적생물학공능엄범이중요,삼여발육、생장、사망등정개생명과정.초과50％적miRNA위우종류상관구역혹취성구역,여종류발생、발전、침습전이관계밀절적miRNA적발현사인문대기인표체조절유료신인식,야위폐암등악성종류침습전이궤제적연구이급miRNA재진단치료중적응용개탁료신시야.문장종술료miRNA재폐암발병궤제중적작용,병탐토기작위폐암진단여예후표지물적가능성급작위잠재치료성파점적응용전경.
MicroRNAs (miRNAs) are a group of multifunctional regulators which plays crucial role in physiological and pathological processed ranging from development,differentiation and apoptosis to stress responscs.Over 50 ％ miRNAs are located in the tumor-associated region or the fragile chrosomal regions which are susceptible to amplification,deletion or translocation during the process of tumor onset and development.More recently,the new publications indicated that the miRNAs broaden the insight for the mechanism research of tumor metastasis and the applications of miRNAs in carcinoma diagnosis.The article focuses on the mechanism by which some miRNAs are deregulated in lung cancer,the clinical potential of these molecules as the diagnosis and prognosis biomarkers and the future of miRNAs to be potential therapeutic drugs.
