CAJ | 학술논문

目的探讨贲门癌患者手术前后血清同型半胱氨酸(Hcy)水平变化及临床意义.方法采用循环酶法检测102例贲门癌患者(其中男性69例)和50名健康人(健康对照组)外周血Hcy的水平.结果男性贲门癌组明显高于健康对照组,差异有统计学意义(t=5.143,P=0.001);男性贲门癌患者术后外周血血清Hey水平显著低于术前(均P＜0.05),术后1个月血清Hey水平明显下降接近于健康对照组;Ⅳ期男性患者血清Hcy水平低于其他TNM分期组,且差异有统计学意义(t值分别为2.306、3.285,P值分别为0.030、0.002);男性患者肿瘤长度＞5cm组Hcy水平明显低于＜3cm、3 ～5 cm组,且差异有统计学意义(t值分别为2.461、2.147,P值分别为0.017、0.038);Logistic回归分析,Hey与男性贲门癌发病有一定的相关性,OR值为1.136(95％CI 1.010～1.278,P=0.033).男性贲门癌患者淋巴结转移与Hcy含量呈负相关(OR=0.865,P=0.010).结论 Hcy水平与男性贲门癌发病风险呈正相关,且与贲门癌的进展有密切关系.
목적 탐토분문암환자수술전후혈청동형반광안산(Hcy)수평변화급림상의의.방법 채용순배매법검측102례분문암환자(기중남성69례)화50명건강인(건강대조조)외주혈Hcy적수평.결과 남성분문암조명현고우건강대조조,차이유통계학의의(t=5.143,P=0.001);남성분문암환자술후외주혈혈청Hey수평현저저우술전(균P＜0.05),술후1개월혈청Hey수평명현하강접근우건강대조조;Ⅳ기남성환자혈청Hcy수평저우기타TNM분기조,차차이유통계학의의(t치분별위2.306、3.285,P치분별위0.030、0.002);남성환자종류장도＞5cm조Hcy수평명현저우＜3cm、3 ～5 cm조,차차이유통계학의의(t치분별위2.461、2.147,P치분별위0.017、0.038);Logistic회귀분석,Hey여남성분문암발병유일정적상관성,OR치위1.136(95％CI 1.010～1.278,P=0.033).남성분문암환자림파결전이여Hcy함량정부상관(OR=0.865,P=0.010).결론 Hcy수평여남성분문암발병풍험정정상관,차여분문암적진전유밀절관계.
Objective To evaluate the changes and clinical significance ot the serum levels of homocysteine (Hcy) in gastric cardia cancer patients before and after surgery.Methods Serum Hcy concentrations of 102 patients with gastric cardia cancer (including 69 case of males) and 50 healthy human were measured by enzymatic cycling assay.Results Total Hcy levels were significantly increased in male patient group compared with the levels in control group (t =5.143,P =0.001).Hcy levels were significantly lower in postoperative group compared with preoperative group [(17.08±5.31) μmol/L vs (20.34±9.26) μmol/L,(14.07±4.87) μmol/L vs (20.34±9.26) μmol/L,P ＜ 0.05].Compared with Ⅳ stage group and other TNM stage groups,significantly lower levels of Hcy were detected in patients with gastric cardia cancer (t =2.306,3.285,P =0.030,0.002).Hcy levels in patients with gastric cardia cancer were also significantly higher than those in the tumor length ＜ 3 cm,3-5 cm and ＞ 5 cm groups (t =2.461,2.147,P =0.017,0.038).Multiple logistic regression analysis indicated a statistically significant association between serum Hcy concentration and gastric cardia cancer incidence (OR =1.136,95 ％ CI 1.010-1.278,P =0.033).Increasing serum Hcy levels were significantly associated with a decreasing risk of metastatic lymph node (OR =0.865,P =0.010).Conclusion Serum Hcy levels are directly associated with risk of male patients with gastric cardia cancer,and play important roles in the development of gastric cardia cancer.