CAJ | 학술논문

目的探讨胃癌患者的治疗结果和预后影响因素.方法回顾性分析经病理证实的179例胃癌患者的临床资料,分析其疗效和预后影响因素.采用Kaplan-Meier法分析生存率,Log-rank检验比较组间生存差异.结果 179例胃癌患者2年总生存(OS)率和无进展生存(PFS)率分别为58.2％和47.8％.T1～2期患者2年OS率明显高于T3～4期者(94.1％比51.7％,P=0.000),N0～1期患者2年OS率明显高于N2～3期者(82.0％比48.4％,P=0.001),TNM分期Ⅰ～Ⅱ期患者2年OS率明显高于Ⅲ～Ⅳ期者(81.2％比49.0％,P=0.003).R0切除患者2年OS率明显高于R1切除者(62.2％比24.1％,P=0.001).接受D2手术患者2年OS率明显高于D0～1者(61.3％比24.7％,P=0.031).T分期、N分期、手术切除方式均为OS和PFS的独立预后影响因素.结论 T分期、N分期、手术切除方式均为胃癌患者OS和PFS明确的独立预后因素,对胃癌患者选择治疗模式和预测远期疗效具有一定的临床意义.
목적 탐토위암환자적치료결과화예후영향인소.방법 회고성분석경병리증실적179례위암환자적림상자료,분석기료효화예후영향인소.채용Kaplan-Meier법분석생존솔,Log-rank검험비교조간생존차이.결과 179례위암환자2년총생존(OS)솔화무진전생존(PFS)솔분별위58.2％화47.8％.T1～2기환자2년OS솔명현고우T3～4기자(94.1％비51.7％,P=0.000),N0～1기환자2년OS솔명현고우N2～3기자(82.0％비48.4％,P=0.001),TNM분기Ⅰ～Ⅱ기환자2년OS솔명현고우Ⅲ～Ⅳ기자(81.2％비49.0％,P=0.003).R0절제환자2년OS솔명현고우R1절제자(62.2％비24.1％,P=0.001).접수D2수술환자2년OS솔명현고우D0～1자(61.3％비24.7％,P=0.031).T분기、N분기、수술절제방식균위OS화PFS적독립예후영향인소.결론 T분기、N분기、수술절제방식균위위암환자OS화PFS명학적독립예후인소,대위암환자선택치료모식화예측원기료효구유일정적림상의의.
Objective To analyze the treatment outcome and prognostic factors of gastric cancer.Methods One hundred and fifty-six pathological confirmed gastric cancer patients were enrolled in this retrospective study.The treatment outcome and prognostic factors were analyzed.Kaplan-Meier method was used to analyze survival rates.The differences between survival curves were calculated by the Log-rank test.Results The 2-year overall survival (OS) and progression-free survival (PFS) rates of 179 gastric cancer patients were 65.8 ％ and 52.1％,respectively.Univariate analysis revealed that T stage,N stage,TNM stage and surgical modality were all closely associated with prognosis.The 2-year OS rate for patients with stage T-2 was superior to those with STAGE T3-4 (94.1％ vs 51.7 ％,P =0.000).Similar results were observed for different N stage and TNM stage patients (N0-1 vs N2-3,82.0 ％ vs 48.4 ％,P =0.001 and Ⅰ-Ⅱ vs Ⅲ-Ⅳ,81.2 ％ vs 49.0 ％,P =0.003,respectively).The 2-year OS rates for patients undergoing R0 and R1 dissection were 62.2 ％ and 24.1％ (P =0.001),respectively.And the corresponding 2-year OS rates for patients undergoing D2 and D0-1 dissection were 61.3 ％ and 24.7 ％ (P =0.031),respectively.Multivariate analysis revealed that T stage,N stage,TNM stage and surgical modality were all independent prognostic factors for OS and PFS.Conclusions T stage,N stage,TNM stage and surgical modality are all independent prognostic factors against OS and PFS for patients with gastric cancer.These results may be applied to predict prognosis and treatment modality selection in the clinic for gastric cancer.