肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
3期
206-209
,共4页
结直肠肿瘤%基因,DPYD%基因变异%药物疗法
結直腸腫瘤%基因,DPYD%基因變異%藥物療法
결직장종류%기인,DPYD%기인변이%약물요법
Colorectal neoplasms%Gene,DPYD%Gene variation%Drug therapy
5-氟尿嘧啶(5-Fu)目前已成为结直肠癌辅助化疗的首选药物,80％以上的5-Fu都是由二氢嘧啶脱氢酶(DPD)代谢降解的.当编码DPD的基因即DPYD基因突变导致DPD部分或完全缺陷时,可引起5-Fu不良反应,包括腹泻、口腔炎、手足综合征及神经毒性等.文章就DPYD基因变异的研究背景、研究现状及对临床的指导意义作一综述.
5-氟尿嘧啶(5-Fu)目前已成為結直腸癌輔助化療的首選藥物,80％以上的5-Fu都是由二氫嘧啶脫氫酶(DPD)代謝降解的.噹編碼DPD的基因即DPYD基因突變導緻DPD部分或完全缺陷時,可引起5-Fu不良反應,包括腹瀉、口腔炎、手足綜閤徵及神經毒性等.文章就DPYD基因變異的研究揹景、研究現狀及對臨床的指導意義作一綜述.
5-불뇨밀정(5-Fu)목전이성위결직장암보조화료적수선약물,80％이상적5-Fu도시유이경밀정탈경매(DPD)대사강해적.당편마DPD적기인즉DPYD기인돌변도치DPD부분혹완전결함시,가인기5-Fu불량반응,포괄복사、구강염、수족종합정급신경독성등.문장취DPYD기인변이적연구배경、연구현상급대림상적지도의의작일종술.
5-fluorouracil (5-Fu) as the most common adjuvant chemotherapy has been widely used for patients with colorectal cancer.As reported dihydropyrimidine dehydrogenase (DPD) has been known as an initial rate-limiting enzyme to catalyze approximately 80 ％ of administered dose of 5-Fu.However,patients with a partial or complete DPD deficiency because of the mutation of DPYD gene may suffer from diarrhea,stomatitis,hand-foot syndrome or neurotoxicity and even death.In this article,the application of DPYD gene screening in patients with colorectal cancer of current status and recent clinical application are reviewed.
