肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
5期
322-324
,共3页
癌,肝细胞%Ki-67%微血管密度%相关性分析
癌,肝細胞%Ki-67%微血管密度%相關性分析
암,간세포%Ki-67%미혈관밀도%상관성분석
Carcinoma,hepatocellular%Ki-67 antigen%Microvessel density%Correlation analysis
目的 探讨原发性肝癌中Ki-67表达水平及微血管密度(MVD)与患者年龄的相关性.方法 应用免疫组织化学法检测肝癌切除标本癌组织Ki-67表达水平及MVD,并分析其与年龄的相关性.结果 48例肝癌组织中Ki-67有程度不同的表达,阳性率为83.3％(40/45),在相应的癌旁组织中Ki-67无表达(P＜0.01).在癌组织及癌旁组织CD34标记的MVD分别为32.17±8.06、10.83±2.85,癌组织的MVD要高于癌旁组织(P＜0.01).肝癌组织中年龄与Ki-67表达水平及MVD均呈负相关(r=-0.418,P=0.003;r=-0.443,P=0.002).结论 肝癌组织中Ki-67表达水平及MVD与患者年龄呈负相关,提示年轻的肝癌患者可能预后更差.
目的 探討原髮性肝癌中Ki-67錶達水平及微血管密度(MVD)與患者年齡的相關性.方法 應用免疫組織化學法檢測肝癌切除標本癌組織Ki-67錶達水平及MVD,併分析其與年齡的相關性.結果 48例肝癌組織中Ki-67有程度不同的錶達,暘性率為83.3％(40/45),在相應的癌徬組織中Ki-67無錶達(P＜0.01).在癌組織及癌徬組織CD34標記的MVD分彆為32.17±8.06、10.83±2.85,癌組織的MVD要高于癌徬組織(P＜0.01).肝癌組織中年齡與Ki-67錶達水平及MVD均呈負相關(r=-0.418,P=0.003;r=-0.443,P=0.002).結論 肝癌組織中Ki-67錶達水平及MVD與患者年齡呈負相關,提示年輕的肝癌患者可能預後更差.
목적 탐토원발성간암중Ki-67표체수평급미혈관밀도(MVD)여환자년령적상관성.방법 응용면역조직화학법검측간암절제표본암조직Ki-67표체수평급MVD,병분석기여년령적상관성.결과 48례간암조직중Ki-67유정도불동적표체,양성솔위83.3％(40/45),재상응적암방조직중Ki-67무표체(P＜0.01).재암조직급암방조직CD34표기적MVD분별위32.17±8.06、10.83±2.85,암조직적MVD요고우암방조직(P＜0.01).간암조직중년령여Ki-67표체수평급MVD균정부상관(r=-0.418,P=0.003;r=-0.443,P=0.002).결론 간암조직중Ki-67표체수평급MVD여환자년령정부상관,제시년경적간암환자가능예후경차.
Objective To investigate the correlation between patient' s age and expression of Ki-67 or microvessel density in primary hepatocellular carcinoma.Methods The expression level of Ki-67 and the microvessel density in the hepatocellular carcinoma tissues were detected by immunohistochemical method,and the correlation between age and expression of Ki-67 or microvessel density were analyzed.Results In 48 cases of hepatocellular carcinoma tissues,Ki-67 expressed to varying degrees,but the positive rate was 83.3 ％ (40/45),and there was no expression in corresponding noncancerous tissues (P ＜ 0.01).Microvessel density marked by CD34 in cancer tissues and noncancerous tissues were 32.17±8.06 and 10.83±2.85 respectively.Microvessel density of cancer tissues was higher than noncancerous tissues (P ＜ 0.01).Both levels of Ki-67 expression and microvessel density in hepatocellular carcinoma were negatively correlated with the age (r =-0.418,P =0.003 and r =-0.443,P =0.002 respectively).Conclusion Both levels of Ki-67 expression and microvessel density in hepatocellular carcinoma are negatively correlated with patient' s age,which may suggest worse prognosis for the younger patients.
