肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
5期
325-327
,共3页
杨钰贤%陈志明%张述耀%林丹霞%张盛奇%庄晓文
楊鈺賢%陳誌明%張述耀%林丹霞%張盛奇%莊曉文
양옥현%진지명%장술요%림단하%장성기%장효문
艾迪注射液%晚期癌症%癌痛%生活质量%疗效
艾迪註射液%晚期癌癥%癌痛%生活質量%療效
애적주사액%만기암증%암통%생활질량%료효
Aidi injection%Advanced cancer%Cancer pain%Quality of life%Curative effect
目的 观察艾迪注射液治疗年老体弱的晚期癌症患者的近期疗效、疼痛缓解情况、生活质量及生存期的影响.方法 将143例老年晚期癌症患者随机数字表法随机分为治疗组和对照组,其中对照组71例,给予对症、支持等常规治疗;治疗组72例,在对照组用药基础上给予艾迪注射液50～60 ml加入0.9％氯化钠溶液250 ml静脉滴注,1次/d,21d为1个疗程,2个疗程结束后评价两组的近期疗效、疼痛缓解情况、生活质量变化及生存期.结果 治疗组有效[完全缓解(CR)+部分缓解(PR)]率仅为2.8％(2/72),对照组无缓解病例;而临床受益[CR+PR+无变化(SD)]率为66.7％(48/72),明显高于对照组31.0％(22/71),差异有统计学意义(P＜0.05).治疗组疼痛缓解总有效率为67.6％(25/37);明显高于对照组36.1％(13/36) (P＜ 0.05).治疗组中位生存期为6.2个月,高于对照组5.1个月(P＞0.05).治疗组治疗前、后生活质量良好率分别为18.1％(13/72)和66.7％(48/72),对照组分别为15.5％(11/71)和22.5％(16/71) (P＜0.05).治疗组不良反应极小.结论 艾迪注射液治疗年老体弱的晚期癌症患者有一定抑制肿瘤生长的作用,能缓解癌痛并提高晚期癌症患者的生活质量,安全,值得临床推广应用.
目的 觀察艾迪註射液治療年老體弱的晚期癌癥患者的近期療效、疼痛緩解情況、生活質量及生存期的影響.方法 將143例老年晚期癌癥患者隨機數字錶法隨機分為治療組和對照組,其中對照組71例,給予對癥、支持等常規治療;治療組72例,在對照組用藥基礎上給予艾迪註射液50～60 ml加入0.9％氯化鈉溶液250 ml靜脈滴註,1次/d,21d為1箇療程,2箇療程結束後評價兩組的近期療效、疼痛緩解情況、生活質量變化及生存期.結果 治療組有效[完全緩解(CR)+部分緩解(PR)]率僅為2.8％(2/72),對照組無緩解病例;而臨床受益[CR+PR+無變化(SD)]率為66.7％(48/72),明顯高于對照組31.0％(22/71),差異有統計學意義(P＜0.05).治療組疼痛緩解總有效率為67.6％(25/37);明顯高于對照組36.1％(13/36) (P＜ 0.05).治療組中位生存期為6.2箇月,高于對照組5.1箇月(P＞0.05).治療組治療前、後生活質量良好率分彆為18.1％(13/72)和66.7％(48/72),對照組分彆為15.5％(11/71)和22.5％(16/71) (P＜0.05).治療組不良反應極小.結論 艾迪註射液治療年老體弱的晚期癌癥患者有一定抑製腫瘤生長的作用,能緩解癌痛併提高晚期癌癥患者的生活質量,安全,值得臨床推廣應用.
목적 관찰애적주사액치료년로체약적만기암증환자적근기료효、동통완해정황、생활질량급생존기적영향.방법 장143례노년만기암증환자수궤수자표법수궤분위치료조화대조조,기중대조조71례,급여대증、지지등상규치료;치료조72례,재대조조용약기출상급여애적주사액50～60 ml가입0.9％록화납용액250 ml정맥적주,1차/d,21d위1개료정,2개료정결속후평개량조적근기료효、동통완해정황、생활질량변화급생존기.결과 치료조유효[완전완해(CR)+부분완해(PR)]솔부위2.8％(2/72),대조조무완해병례;이림상수익[CR+PR+무변화(SD)]솔위66.7％(48/72),명현고우대조조31.0％(22/71),차이유통계학의의(P＜0.05).치료조동통완해총유효솔위67.6％(25/37);명현고우대조조36.1％(13/36) (P＜ 0.05).치료조중위생존기위6.2개월,고우대조조5.1개월(P＞0.05).치료조치료전、후생활질량량호솔분별위18.1％(13/72)화66.7％(48/72),대조조분별위15.5％(11/71)화22.5％(16/71) (P＜0.05).치료조불량반응겁소.결론 애적주사액치료년로체약적만기암증환자유일정억제종류생장적작용,능완해암통병제고만기암증환자적생활질량,안전,치득림상추엄응용.
Objective To evaluate the effects of Aidi injection on the short-term curative effect,pain level,quality of life and the survival time for the elderly and infirm patients with advanced cancer.Methods A total of 143 elderly patients with advanced cancer were randomly divided into two groups,71 patients in control group were treated with routine support therapies,and 72 patients in treatment group were injected with 50-60 ml Aidi injection infused in NS 250 ml by i.v drip every day combined with routine medicines,each cycle was 21 days,all patients were received for 2 cycles.Results After treatment the short-term curative effect rate (CR+PR) was 2.8 ％ (2/72) only compared with no effect of control group.But the effective and stabilization rate (CR+PR+SD) was 66.7 ％ (48/72),it was 31.0 ％ (22/71) in control group.There was significant difference between the two groups (P ＜ 0.05).The overall effective rate of easement of pain was 67.7 ％ (48/72) in treatment group versus 36.1％ (13/36) in control group (P ＜ 0.05).The median survival time (MST) was 6.2 months in treatment group versus 5.1 months in control group (P ＞ 0.05).The quality of life in treatment group was improved obviously (P ＜ 0.05).The side effects of patients in treatment group were very slight.Conclusions Aidi injection can reduce the cancer pain,improve the quality of life and prolong the survival time of the elderly and infirm patients with advanced cancer.It is safe,and effective to inhibit growth of tumor.It can be recommended widely to clinical use.
