肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
6期
400-402
,共3页
子宫颈肿瘤%腺癌%子宫颈腺上皮内瘤变%人角化层糜蛋白酶%免疫组织化学
子宮頸腫瘤%腺癌%子宮頸腺上皮內瘤變%人角化層糜蛋白酶%免疫組織化學
자궁경종류%선암%자궁경선상피내류변%인각화층미단백매%면역조직화학
Uterine cervical neoplasms%Adenocarcinoma Cervical glandular intraepithelial neoplasia%Stratum corneum chymotryptic enzyme%Immunohistochemistry
目的 研究人角化层糜蛋白酶(SCCE)在子宫颈腺癌中的表达及临床意义.方法 采用免疫组织化学SP法检测子宫颈腺癌45例、子宫颈腺上皮内瘤变(CGIN) 24例和正常子宫颈组织24例中SCCE、雌激素受体(ER)、癌胚抗原(CEA)及波形蛋白(Vimentin)的表达情况.结果 子宫颈腺癌、CGIN和正常子宫颈组中,SCCE的阳性表达率分别为84.44％(38/45)、58.33％(14/24)和8.33％(2/24),子宫颈腺癌组中SCCE表达率明显高于正常子宫颈组(P＜ 0.012 5),CGIN组中SCCE表达率高于正常子宫颈组(P＜0.0125),子宫颈腺癌组与CGIN组SCCE表达率差异无统计学意义(P＞0.0125).结论 SCCE可以作为子宫颈腺癌早期筛查中的一项新指标,并可作为判断预后的指标.
目的 研究人角化層糜蛋白酶(SCCE)在子宮頸腺癌中的錶達及臨床意義.方法 採用免疫組織化學SP法檢測子宮頸腺癌45例、子宮頸腺上皮內瘤變(CGIN) 24例和正常子宮頸組織24例中SCCE、雌激素受體(ER)、癌胚抗原(CEA)及波形蛋白(Vimentin)的錶達情況.結果 子宮頸腺癌、CGIN和正常子宮頸組中,SCCE的暘性錶達率分彆為84.44％(38/45)、58.33％(14/24)和8.33％(2/24),子宮頸腺癌組中SCCE錶達率明顯高于正常子宮頸組(P＜ 0.012 5),CGIN組中SCCE錶達率高于正常子宮頸組(P＜0.0125),子宮頸腺癌組與CGIN組SCCE錶達率差異無統計學意義(P＞0.0125).結論 SCCE可以作為子宮頸腺癌早期篩查中的一項新指標,併可作為判斷預後的指標.
목적 연구인각화층미단백매(SCCE)재자궁경선암중적표체급림상의의.방법 채용면역조직화학SP법검측자궁경선암45례、자궁경선상피내류변(CGIN) 24례화정상자궁경조직24례중SCCE、자격소수체(ER)、암배항원(CEA)급파형단백(Vimentin)적표체정황.결과 자궁경선암、CGIN화정상자궁경조중,SCCE적양성표체솔분별위84.44％(38/45)、58.33％(14/24)화8.33％(2/24),자궁경선암조중SCCE표체솔명현고우정상자궁경조(P＜ 0.012 5),CGIN조중SCCE표체솔고우정상자궁경조(P＜0.0125),자궁경선암조여CGIN조SCCE표체솔차이무통계학의의(P＞0.0125).결론 SCCE가이작위자궁경선암조기사사중적일항신지표,병가작위판단예후적지표.
Objective To investigate the expression of stratum corneum chymotuptic enzyme (SCCE) and its significance in human cervical adenocarcinoma.Methods Immunohistochemistry was used to detect the expressions of SCCE,ER,CEA and Vimentin in tissues from the group of 45 cervical adenocarcinoma patients,group of 24 cervical glandular intraepithelial neoplasia (CGIN) patients and group of 24 normal cervical tissues.Results The expression of SCCE was 84.44 ％ (38/45),58.33 ％ (14/24) and 8.33 ％ (2/24) in 3 groups respectively.The SCCE expression from group of cervical adenocarcinoma were more significantly than that of normal cervical tissues (P ＜ 0.012 5),the expression of SCCE from group of CGIN were more significantly than that of normal cervical tissues (P ＜ 0.012 5),but there was no difference between the cervical adenocarcinoma and the CGIN on the expression of SCCE (P ＞ 0.012 5).Conclusion SCCE could be recommended as a new biomarker for the early screening cervical adenocarcinoma and as an additional marker for the prognosis of cervical adenocarcinoma.
