CAJ | 학술논문

目的探讨ING4表达水平与原发乳腺癌的关系.方法收集原发乳腺癌患者的肿瘤组织和外周血标本,免疫组织化学法检测乳腺癌组织标本中的ING4及NF-κB表达;酶联免疫吸附法(ELISA)检测乳腺癌患者外周血中ING4的表达.结果乳腺癌组织中ING4及NF-κB表达阳性率较癌旁组织高[100.00％(30/30)比12.50％(3/24),93.75％(45/48)比6.67％(1/15)];乳腺癌患者术后外周血ING4水平较术前降低(P=0.044).结论 ING4的整体表达在临床原发乳腺癌患者中并未降低,可能是由于在肿瘤早期,机体应激反应性高分泌ING4以对抗肿瘤的发展.
목적 탐토ING4표체수평여원발유선암적관계.방법 수집원발유선암환자적종류조직화외주혈표본,면역조직화학법검측유선암조직표본중적ING4급NF-κB표체;매련면역흡부법(ELISA)검측유선암환자외주혈중ING4적표체.결과 유선암조직중ING4급NF-κB표체양성솔교암방조직고[100.00％(30/30)비12.50％(3/24),93.75％(45/48)비6.67％(1/15)];유선암환자술후외주혈ING4수평교술전강저(P=0.044).결론 ING4적정체표체재림상원발유선암환자중병미강저,가능시유우재종류조기,궤체응격반응성고분비ING4이대항종류적발전.
Objective To investigate the relationship between the expression of ING4 and clinical primary breast cancer.Methods Tissue and peripheral blood samples of primary breast cancer patients were collected and the expression levels of ING4 and NF-κB in tissue samples were detected with immunohistochemistry.The expression of ING4 in the peripheral blood was detected with ELISA.Results The positive rates of expression of ING4 and NF-κB in breast cancer tissues were 100.00 ％ (30/30),which were significantly higher than that in the adjacent tissues 12.50 ％ (3/24) and 93.75 ％ (45/48) compared to 6.67 ％ (1/15) respectively.Compared with the preoperative,the ING4 level in peripheral blood from the postoperative breast cancer patients was significantly reduced (P =0.044).Conclusions The expression of ING4 does not decrease in the primary breast cancer patients.The increasing is perhaps due to the body's stress response against tumor development in early stage by secreting more ING4 protein.