CAJ | 학술논문

微小RNA(miRNA)是一类小分子非编码调控性RNA,以细胞及组织特异性方式表达,在维持细胞自身稳态及癌变过程中具有关键性作用.近年来,研究表明许多特异性miRNA与恶性黑色素瘤的发生发展有关.黑色素瘤相关性miRNA通常定位于肿瘤易发生基因扩增及缺失的基因组区域.文章旨在探讨特异性miRNA通过各种途径对不同靶基因的调控从而参与恶性黑色素瘤的生物学进程,并描述了黑色素瘤的治疗现状.
미소RNA(miRNA)시일류소분자비편마조공성RNA,이세포급조직특이성방식표체,재유지세포자신은태급암변과정중구유관건성작용.근년래,연구표명허다특이성miRNA여악성흑색소류적발생발전유관.흑색소류상관성miRNA통상정위우종류역발생기인확증급결실적기인조구역.문장지재탐토특이성miRNA통과각충도경대불동파기인적조공종이삼여악성흑색소류적생물학진정,병묘술료흑색소류적치료현상.
microRNAs (miRNAs) are small,non-coding,regulatory RNA molecules group expressed in tissues and cells in specific manner.They are well-known as playing crucial roles in cell homeostasis and carcinogenesis.In recent years,numerou of studys on individual miRNAs or miRNA patterns have been published.These study provided strong evidences that miRNAs might play important roles in malignant melanoma development and progression.Melanoma associated miRNAs often located in genomic regions with frequent gains and losses in tumours.This article focus on some individual miRNAs which involved in melanoma biology,by which may regulate many different target genes by several ways.The current therapy of this disease is also described.