肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
7期
473-475
,共3页
胆管肿瘤%体部伽玛刀%黄疸,梗阻性%疗效
膽管腫瘤%體部伽瑪刀%黃疸,梗阻性%療效
담관종류%체부가마도%황달,경조성%료효
Bile duct neoplasms%Body gama-knife%Jaundice,obstructive%Efficacy
目的 观察体部伽玛刀治疗胆管癌所致恶性梗阻性黄疸患者的症状改善情况、近期和远期疗效.方法 对76例胆管癌所致恶性梗阻性黄疸患者采用OUR-QGD体部伽玛刀治疗.单次治疗剂量为3.0 ～ 4.0 Gy,等剂量曲线为50.0％～65.0％,共计10～12次.治疗中监测肝功能、血常规及不良反应.治疗后定期随访观察患者症状的改善情况,评价近期疗效和远期生存.结果 76例患者中,69例黄疸症状明显减轻,且总胆红素及丙氨酸氨基转移酶水平较治疗前降低(P＜0.05);客观缓解率为88.16％(67/76),疾病控制率为90.79％(69/76).患者中位疾病进展时间为8.8个月,中位总生存时间为13.4个月.结论 采用体部伽玛刀治疗胆管癌所致恶性梗阻性黄疸可显著改善患者的症状,提高患者的生存质量.该疗法患者不良反应小,近远期疗效均较为满意.
目的 觀察體部伽瑪刀治療膽管癌所緻噁性梗阻性黃疸患者的癥狀改善情況、近期和遠期療效.方法 對76例膽管癌所緻噁性梗阻性黃疸患者採用OUR-QGD體部伽瑪刀治療.單次治療劑量為3.0 ～ 4.0 Gy,等劑量麯線為50.0％～65.0％,共計10～12次.治療中鑑測肝功能、血常規及不良反應.治療後定期隨訪觀察患者癥狀的改善情況,評價近期療效和遠期生存.結果 76例患者中,69例黃疸癥狀明顯減輕,且總膽紅素及丙氨痠氨基轉移酶水平較治療前降低(P＜0.05);客觀緩解率為88.16％(67/76),疾病控製率為90.79％(69/76).患者中位疾病進展時間為8.8箇月,中位總生存時間為13.4箇月.結論 採用體部伽瑪刀治療膽管癌所緻噁性梗阻性黃疸可顯著改善患者的癥狀,提高患者的生存質量.該療法患者不良反應小,近遠期療效均較為滿意.
목적 관찰체부가마도치료담관암소치악성경조성황달환자적증상개선정황、근기화원기료효.방법 대76례담관암소치악성경조성황달환자채용OUR-QGD체부가마도치료.단차치료제량위3.0 ～ 4.0 Gy,등제량곡선위50.0％～65.0％,공계10～12차.치료중감측간공능、혈상규급불량반응.치료후정기수방관찰환자증상적개선정황,평개근기료효화원기생존.결과 76례환자중,69례황달증상명현감경,차총담홍소급병안산안기전이매수평교치료전강저(P＜0.05);객관완해솔위88.16％(67/76),질병공제솔위90.79％(69/76).환자중위질병진전시간위8.8개월,중위총생존시간위13.4개월.결론 채용체부가마도치료담관암소치악성경조성황달가현저개선환자적증상,제고환자적생존질량.해요법환자불량반응소,근원기료효균교위만의.
Objective To observe the symptoms,short and long term effects of body gama-knife in treatment of obstructive jaundice caused by cholangiocarcinoma.Methods 76 patients with obstructive jaundice caused by cholangiocarcinoma were treated with OUR-QGD body gamma-knife.The single therapeutic dose was 3.0-4.0 Gy,isodose curves was 50.0 ％-65.0 ％,the total treatment time was 10-12 times.The liver function,blood routine and adverse effects were monitored.Results Among 76 patients,the jaundice symptoms of 69 cases were significantly reduced,the TBIL and ALT levels were significantly lower than that before treatment (P ＜ 0.05),the ORR was 88.16 ％ (67/76),DCR was 90.79 ％ (69/76).The median TTP was 8.8 months and the median OS was 13.4 months.Conclusions Body gamma-knife treatment for obstructive jaundice caused by cholangiocarcinoma can significantly improve symptoms of patients,and improve their life quality.This treatment has less adverse effects and satisfaction short-time and long-term effects.
