肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
8期
523-526
,共4页
刘虹%木合拜尔·阿布都尔%张玥玥%王晓敏
劉虹%木閤拜爾·阿佈都爾%張玥玥%王曉敏
류홍%목합배이·아포도이%장모모%왕효민
白血病,淋巴样%核型分析%治疗结果
白血病,淋巴樣%覈型分析%治療結果
백혈병,림파양%핵형분석%치료결과
Leukemia,lymphoid%Karyotyping%Treatment outcome
目的 探讨急性淋巴细胞白血病(ALL)患者的染色体核型特点及其与疗效的关系.方法 采用短期培养法、R显带技术对80例ALL患者骨髓染色体核型进行分析.结果 80例ALL患者中,正常核型53例(66.2％),异常核型27例(33.8％),其中,染色体核型结构异常者10例(12.5％),数目异常者2例(2.5％),复杂异常15例(18.8％).按数目畸变分类,＞ 50的超二倍体2例(2.5％)、47～50的超二倍体5例(6.25％)、假二倍体18例(22.5％)、正常二倍体53例(66.25％)、亚二倍体2例(2.5％)、未见近三倍体或近四倍体.正常核型患者疗效优于异常核型患者(x2=19.371,P＜ 0.01),复杂核型患者疗效差于其他核型患者(x2=9.145,P=0.004),伴有t(9;22)(q34;q11)患者疗效差于其他核型患者(x2=5.785,P=0.021).结论 ALL患者的染色体核型异常具有随机性,常见的异常核型为复杂核型和伴有t(9;22)(q34;q11)核型,其疗效均较差.
目的 探討急性淋巴細胞白血病(ALL)患者的染色體覈型特點及其與療效的關繫.方法 採用短期培養法、R顯帶技術對80例ALL患者骨髓染色體覈型進行分析.結果 80例ALL患者中,正常覈型53例(66.2％),異常覈型27例(33.8％),其中,染色體覈型結構異常者10例(12.5％),數目異常者2例(2.5％),複雜異常15例(18.8％).按數目畸變分類,＞ 50的超二倍體2例(2.5％)、47～50的超二倍體5例(6.25％)、假二倍體18例(22.5％)、正常二倍體53例(66.25％)、亞二倍體2例(2.5％)、未見近三倍體或近四倍體.正常覈型患者療效優于異常覈型患者(x2=19.371,P＜ 0.01),複雜覈型患者療效差于其他覈型患者(x2=9.145,P=0.004),伴有t(9;22)(q34;q11)患者療效差于其他覈型患者(x2=5.785,P=0.021).結論 ALL患者的染色體覈型異常具有隨機性,常見的異常覈型為複雜覈型和伴有t(9;22)(q34;q11)覈型,其療效均較差.
목적 탐토급성림파세포백혈병(ALL)환자적염색체핵형특점급기여료효적관계.방법 채용단기배양법、R현대기술대80례ALL환자골수염색체핵형진행분석.결과 80례ALL환자중,정상핵형53례(66.2％),이상핵형27례(33.8％),기중,염색체핵형결구이상자10례(12.5％),수목이상자2례(2.5％),복잡이상15례(18.8％).안수목기변분류,＞ 50적초이배체2례(2.5％)、47～50적초이배체5례(6.25％)、가이배체18례(22.5％)、정상이배체53례(66.25％)、아이배체2례(2.5％)、미견근삼배체혹근사배체.정상핵형환자료효우우이상핵형환자(x2=19.371,P＜ 0.01),복잡핵형환자료효차우기타핵형환자(x2=9.145,P=0.004),반유t(9;22)(q34;q11)환자료효차우기타핵형환자(x2=5.785,P=0.021).결론 ALL환자적염색체핵형이상구유수궤성,상견적이상핵형위복잡핵형화반유t(9;22)(q34;q11)핵형,기료효균교차.
Objective To explore the chromosome kauotype characteristics and the relationship with curative effect in the acute lymphoblastic leukemia (ALL).Methods The bone marrow cells were collected using a short-term culture method.The R banding technique of chromosome karyotype analysis was used in 80 cases of ALL patients.Results Normal karyotype were found in 53 cases (66.2 ％),and abnormal karyotype in 27 cases (33.8 ％),including structure of chromosome karyotype in 10 cases (12.5 ％),chromosome numerical abnormality in 2 cases (2.5 ％),abnormal complex karyotype in 15 cases (18.8 ％).According to the classification number of distortion,it was found that ＞ 50 diploid in 2 cases (2.5 ％),47-50 diploid in 5 cases (6.25 ％),false diploid in 18 cases (22.5 ％),normal diploid in 53 cases (66.25 ％),the diploid in 2 cases (2.5 ％),it did not shown any karyotype was triploid or nearly four times.The curative effect of normal karyotype was superior to that of the abnormal karyotype (x2 =19.371,P ＜ 0.01),that of complex karyotype had poorer than that of other karyotype (x2 =9.145,P =0.004),and patients accompaning with the t(9;22)(q34;q11) had poorer than that of other karyotype (x2 =5.785,P =0.021).Conclusions The abnormal chromosome karyotype is random.More common abnormal karyotype is complex karyotype and t(9;22) (q34;q11),which curative effects are poorer.
