肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
8期
544-546,549
,共4页
张沛刚%陈永宏%陈钢%马秉灵%贺丕瑞
張沛剛%陳永宏%陳鋼%馬秉靈%賀丕瑞
장패강%진영굉%진강%마병령%하비서
食管肿瘤%Ki-67%c-myc%p53%免疫组织化学
食管腫瘤%Ki-67%c-myc%p53%免疫組織化學
식관종류%Ki-67%c-myc%p53%면역조직화학
Esophageal neoplasms%Ki-67%c-myc%p53%Immunohistochemistry
目的 探讨Ki-67、c-myc、p53在食管癌中的表达及其意义.方法 选取食管癌标本25例、切缘远端正常组织标本25例,采用免疫组织化学法检测组织中Ki-67、c-myc、p53蛋白的表达情况.结果 食管癌组织中Ki-67、c-myc、p53中位表达量分别为5.0、2.0、3.0,明显高于癌旁正常组织的1.0、0.5、0.3(均P＜0.05).高分化食管癌组织Ki-67中位表达量(3.0)低于中低分化组(6.0),差异有统计学意义(P＜0.05).食管癌组织Ki-67与c-myc的表达呈正相关(P＜0.05).结论 食管癌组织中Ki-67、c-myc、p53高表达,且随分化程度升高而升高,Ki-67、c-myc、p53有望成为食管癌的肿瘤标志物.
目的 探討Ki-67、c-myc、p53在食管癌中的錶達及其意義.方法 選取食管癌標本25例、切緣遠耑正常組織標本25例,採用免疫組織化學法檢測組織中Ki-67、c-myc、p53蛋白的錶達情況.結果 食管癌組織中Ki-67、c-myc、p53中位錶達量分彆為5.0、2.0、3.0,明顯高于癌徬正常組織的1.0、0.5、0.3(均P＜0.05).高分化食管癌組織Ki-67中位錶達量(3.0)低于中低分化組(6.0),差異有統計學意義(P＜0.05).食管癌組織Ki-67與c-myc的錶達呈正相關(P＜0.05).結論 食管癌組織中Ki-67、c-myc、p53高錶達,且隨分化程度升高而升高,Ki-67、c-myc、p53有望成為食管癌的腫瘤標誌物.
목적 탐토Ki-67、c-myc、p53재식관암중적표체급기의의.방법 선취식관암표본25례、절연원단정상조직표본25례,채용면역조직화학법검측조직중Ki-67、c-myc、p53단백적표체정황.결과 식관암조직중Ki-67、c-myc、p53중위표체량분별위5.0、2.0、3.0,명현고우암방정상조직적1.0、0.5、0.3(균P＜0.05).고분화식관암조직Ki-67중위표체량(3.0)저우중저분화조(6.0),차이유통계학의의(P＜0.05).식관암조직Ki-67여c-myc적표체정정상관(P＜0.05).결론 식관암조직중Ki-67、c-myc、p53고표체,차수분화정도승고이승고,Ki-67、c-myc、p53유망성위식관암적종류표지물.
Objective To investigate the role of Ki-67,c-myc,p53 in human in esophageal cancer.Methods 25 specimens of human esophageal cancer as observe group and 25 adjacent normal specimens as control group were selected.Expressions of Ki-67,c-myc,p53 protein were detected by immunohistochemical staining.Results Protein expressions levels of Ki-67,c-myc and p53 in human esophageal cancer were significantly higher than those in control group 5.0,2.0,3.0 vs 1.0,0.5,0.3,respectively (all P ＜ 0.05).The expression level of Ki-67 protein in high differentiation group were significantly lower than that of moderate and low differentiation group (3.0 vs 6.0,P ＜ 0.05).In human esophageal cancer specimens,the expression level of Ki-67 protein was positively correlated with that of c-myc (P ＜ 0.05).Conclusion The expressions of Ki-67,c-myc and p53 are higher in esophageal cancer,which are increased with the higher differentiation.Ki-67,c-myc and p53 proteins may be taken as potential markers in human esophageal cancer.
