CAJ | 학술논문

紫杉醇是目前最有效的抗癌药物之一,但由于它的水溶性、药代动力学和体内分布性能较差,且其增溶剂对人体有很强的毒副作用,限制了它的临床应用.为了提高紫杉醇的水溶性、渗透率及稳定性,研究人员制备出一种具有缓释作用、可控及肿瘤靶向的药物——透明质酸-紫杉醇纳米制剂.以透明质酸为载体的纳米载药系统可以降低紫杉醇的毒副作用,利用合适的给药途径将透明质酸-紫杉醇纳米制剂输送至体内,提高了药物的靶向性、水溶性及长循环能力,使药物通过扩散、包吞或受体介导的内吞作用进入细胞.文章综述了透明质酸-紫杉醇纳米制剂在多种恶性肿瘤中的应用.
자삼순시목전최유효적항암약물지일,단유우타적수용성、약대동역학화체내분포성능교차,차기증용제대인체유흔강적독부작용,한제료타적림상응용.위료제고자삼순적수용성、삼투솔급은정성,연구인원제비출일충구유완석작용、가공급종류파향적약물——투명질산-자삼순납미제제.이투명질산위재체적납미재약계통가이강저자삼순적독부작용,이용합괄적급약도경장투명질산-자삼순납미제제수송지체내,제고료약물적파향성、수용성급장순배능력,사약물통과확산、포탄혹수체개도적내탄작용진입세포.문장종술료투명질산-자삼순납미제제재다충악성종류중적응용.
Paclitaxel is one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers.However,its clinical application has been limited due to its poor water solubility.Its current clinical administration results in serious side effects and has undesired pharmacokinetics and biodistribution.Therefore,it is need to develope alternate drug delivery systems of paclitaxel to enhance its solubility,permeability and stability,furthermore to promote a sustained,controlled and targeted delivery.Hyaluronic acid as the carrier of drug delivery system can solve the problems.Hyaluronic acid-paclitaxel nanoparticles have high anticancer efficiency in drug encapsulation and tumor cellular uptake,due to their appropriate size,surface modification and interaction with CD44.This review focuses on recent applications of hyaluronic acid-paclitaxel nanoparticles in a variety of malignant tumors.