肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
9期
638-640
,共3页
硼替佐米%多发性骨髓瘤%周围神经病变
硼替佐米%多髮性骨髓瘤%週圍神經病變
붕체좌미%다발성골수류%주위신경병변
Bortezomib%Multiple myeloma%Peripheral neuropathy
蛋白酶体抑制剂硼替佐米已被用于多种肿瘤的治疗,其最大的毒副作用为周围神经病变,限制了其临床应用.文章简述了硼替佐米所致周围神经病变(BIPN)的病因、危险因素、病理机制、临床表现和分级、检测及评估方法,并介绍了BIPN的防治方法.
蛋白酶體抑製劑硼替佐米已被用于多種腫瘤的治療,其最大的毒副作用為週圍神經病變,限製瞭其臨床應用.文章簡述瞭硼替佐米所緻週圍神經病變(BIPN)的病因、危險因素、病理機製、臨床錶現和分級、檢測及評估方法,併介紹瞭BIPN的防治方法.
단백매체억제제붕체좌미이피용우다충종류적치료,기최대적독부작용위주위신경병변,한제료기림상응용.문장간술료붕체좌미소치주위신경병변(BIPN)적병인、위험인소、병리궤제、림상표현화분급、검측급평고방법,병개소료BIPN적방치방법.
Proteasome inhibitor bortezomib has been used to treat various of tumors,its most important side effect is peripheral neuropathy,which limits its clinical application.This paper briefly described the etiology and risk factors of bortezomib-induced peripheral neuropathy (BIPN),the pathological mechanism,the clinical manifestation,the method of detection and evaluation.And the prevention and treatment of BIPN are introduced.
