肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
10期
677-678,682
,共3页
胃肿瘤%外科手术%淋巴细胞
胃腫瘤%外科手術%淋巴細胞
위종류%외과수술%림파세포
Stomach neoplasms%Surgical procedures,operative%Lymphocytes
目的 探讨根治性手术对胃癌患者外周血中CD4+ CD25+调节性T细胞(Treg细胞)的影响.方法 采用流式细胞术检测58例胃癌患者根治术前和术后7d及10名健康志愿者外周血CD4+CD25+ Treg细胞比例,对其进行比较.结果 健康对照者与胃癌患者术前外周血中CD4+ CD25+ Treg细胞比例分别为(1.1±0.4)％和(1.5±0.5)％,差异有统计学意义(P＜0.05);胃癌患者术后CD4+ CD25+Treg细胞比例为(1.9±0.8)％,与术前相比差异有统计学意义(P＜0.01).结论 胃癌患者免疫功能较健康人低下,手术治疗可能导致免疫功能的进一步低下.
目的 探討根治性手術對胃癌患者外週血中CD4+ CD25+調節性T細胞(Treg細胞)的影響.方法 採用流式細胞術檢測58例胃癌患者根治術前和術後7d及10名健康誌願者外週血CD4+CD25+ Treg細胞比例,對其進行比較.結果 健康對照者與胃癌患者術前外週血中CD4+ CD25+ Treg細胞比例分彆為(1.1±0.4)％和(1.5±0.5)％,差異有統計學意義(P＜0.05);胃癌患者術後CD4+ CD25+Treg細胞比例為(1.9±0.8)％,與術前相比差異有統計學意義(P＜0.01).結論 胃癌患者免疫功能較健康人低下,手術治療可能導緻免疫功能的進一步低下.
목적 탐토근치성수술대위암환자외주혈중CD4+ CD25+조절성T세포(Treg세포)적영향.방법 채용류식세포술검측58례위암환자근치술전화술후7d급10명건강지원자외주혈CD4+CD25+ Treg세포비례,대기진행비교.결과 건강대조자여위암환자술전외주혈중CD4+ CD25+ Treg세포비례분별위(1.1±0.4)％화(1.5±0.5)％,차이유통계학의의(P＜0.05);위암환자술후CD4+ CD25+Treg세포비례위(1.9±0.8)％,여술전상비차이유통계학의의(P＜0.01).결론 위암환자면역공능교건강인저하,수술치료가능도치면역공능적진일보저하.
Objective To investigate the efforts of CD4+ CD25+ regulatory T (Treg) cell adjustment of Treg cells proportion in peripheral blood of patients with gastric cancer before or after surgery.Methods The peripheral blood samples were collected from 10 healthy volunteers,58 gastric cancer patients 2 days before and 7 days after operation.The proportion of Treg cells in peripheral blood were detected by flow cytometry.Results CD4+ CD25+ Treg cell in peripheral blood of patients with gastric cancer increased significantly compared with that of healthy control group (1.1±0.4) ％ / (1.5±0.5) ％ (P ＜ 0.05),and further increased after operation (1.5±0.55) ％ / (1.9±0.8) ％ (P ＜ 0.01).Conclusion The anti-tumor activity in gastric cancer patients is inhibited and surgery may be involved immune defection to decrease this effort.
