肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
10期
703-707
,共5页
癌,非小细胞肺%腺癌%驱动突变%个体化治疗
癌,非小細胞肺%腺癌%驅動突變%箇體化治療
암,비소세포폐%선암%구동돌변%개체화치료
Neoplasms,non-small cell lung%Adenocarcinoma%Driver mutations%Individualized treatment
随着主要肿瘤基因测序项目的开展,来源于体细胞突变的驱动突变以其在癌症发生、发展、治疗中的重要作用受到广泛关注.新驱动突变的不断确认使人们对非小细胞肺癌(NSCLC)的认识从传统的病理分类到现今的基于分子水平改变的分子分型;NSCLC患者也已不再被看做是同一类型肿瘤的集合,而是多种具有不同分子生物学行为、对不同的靶向药物敏感的患者群体.文章着重就NSCLC中腺癌这一特殊病理类型的常见驱动突变及相关转化性医学研究进展作一概述.
隨著主要腫瘤基因測序項目的開展,來源于體細胞突變的驅動突變以其在癌癥髮生、髮展、治療中的重要作用受到廣汎關註.新驅動突變的不斷確認使人們對非小細胞肺癌(NSCLC)的認識從傳統的病理分類到現今的基于分子水平改變的分子分型;NSCLC患者也已不再被看做是同一類型腫瘤的集閤,而是多種具有不同分子生物學行為、對不同的靶嚮藥物敏感的患者群體.文章著重就NSCLC中腺癌這一特殊病理類型的常見驅動突變及相關轉化性醫學研究進展作一概述.
수착주요종류기인측서항목적개전,래원우체세포돌변적구동돌변이기재암증발생、발전、치료중적중요작용수도엄범관주.신구동돌변적불단학인사인문대비소세포폐암(NSCLC)적인식종전통적병리분류도현금적기우분자수평개변적분자분형;NSCLC환자야이불재피간주시동일류형종류적집합,이시다충구유불동분자생물학행위、대불동적파향약물민감적환자군체.문장착중취NSCLC중선암저일특수병리류형적상견구동돌변급상관전화성의학연구진전작일개술.
With the development of the main tumor gene sequencing projects,driver mutations have been put into the highlight due to its significant meaning on the cancer occurrence,development as well as treatment.In the past decade,based on the finding of new driver mutations,the knowledge of non-small cell lung cancer (NSCLC) have been improved from the traditional pathological classification to the current molecular classification.Meanwhile,NSCLC patients are no longer looked as an assembly of the same type tumor but various individuals with different molecular biology behavior with the different sensitivity to the targeted drugs.This article focuses on the recent discovery advances of driver mutations in lung adenocarcinoma.
