中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
21期
10-11
,共2页
生长抑素%恶性肠梗阻%胃肠道肿瘤
生長抑素%噁性腸梗阻%胃腸道腫瘤
생장억소%악성장경조%위장도종류
Somatostatin%Malignant bowel obstruction%Gastrointestinal carcinoma
目的 探讨生长抑素联合长期全肠外营养(TPN)在胃肠道肿瘤所致恶性肠梗阻治疗中的作用.方法 将2003年1月至2008年6月的29例胃肠道恶性肿瘤所致恶性肠梗阻患者随机分为对照组(单独TPN治疗)11例、治疗组(生长抑素联合TPN治疗,其中奥曲肽100 μg皮下注射,3次/d,用药2周)18例,比较两组治疗前后的疗效差异.结果 治疗组临床症状较对照组明显改善,腹痛、腹胀缓解率分别为83.33%、45.45%;肛门排气比例分别为66.67%、27.27%;治疗组胃肠减压量比对照组减少尤为显著;生活质量明显改善,治疗组治疗后其生存质量评分(KPS)分值88.89%的患者高于60分.结论 在恶性肠梗阻患者中,常规TPN治疗时联合应用生长抑素,能够明显改善患者的临床症状和生活质量.
目的 探討生長抑素聯閤長期全腸外營養(TPN)在胃腸道腫瘤所緻噁性腸梗阻治療中的作用.方法 將2003年1月至2008年6月的29例胃腸道噁性腫瘤所緻噁性腸梗阻患者隨機分為對照組(單獨TPN治療)11例、治療組(生長抑素聯閤TPN治療,其中奧麯肽100 μg皮下註射,3次/d,用藥2週)18例,比較兩組治療前後的療效差異.結果 治療組臨床癥狀較對照組明顯改善,腹痛、腹脹緩解率分彆為83.33%、45.45%;肛門排氣比例分彆為66.67%、27.27%;治療組胃腸減壓量比對照組減少尤為顯著;生活質量明顯改善,治療組治療後其生存質量評分(KPS)分值88.89%的患者高于60分.結論 在噁性腸梗阻患者中,常規TPN治療時聯閤應用生長抑素,能夠明顯改善患者的臨床癥狀和生活質量.
목적 탐토생장억소연합장기전장외영양(TPN)재위장도종류소치악성장경조치료중적작용.방법 장2003년1월지2008년6월적29례위장도악성종류소치악성장경조환자수궤분위대조조(단독TPN치료)11례、치료조(생장억소연합TPN치료,기중오곡태100 μg피하주사,3차/d,용약2주)18례,비교량조치료전후적료효차이.결과 치료조림상증상교대조조명현개선,복통、복창완해솔분별위83.33%、45.45%;항문배기비례분별위66.67%、27.27%;치료조위장감압량비대조조감소우위현저;생활질량명현개선,치료조치료후기생존질량평분(KPS)분치88.89%적환자고우60분.결론 재악성장경조환자중,상규TPN치료시연합응용생장억소,능구명현개선환자적림상증상화생활질량.
Objective To investigate the effects of somatostatin combined with total parenteral nutrition(TPN) on malignant bowel obstruction(MBO) due to inoperable gastrointestiinal carcinoma. Methods From Jan. 2003 to Jun. 2008, 29 patients with MBO due inoperable gastrointestinal carcinoma were randomly divided into two groups:the control group(only TPN group) 11 cases and the treatment group(somatostatin combined with TPN) 18 cases(octreotide, 100 μg, subcutaneous injection, tid, for two weeks). The effects were compared between the two groups. Resuits After the treatment, the clinical symptoms of abdominal distention and abdominal pain were relieved significantly (83.33% to 45.45%), the echaust of anus was 66.67% to 27.27%. The average volume of gastroenteral decom-pression reduced more efficiently. Qaality of life, evaluated with Karnofsky score, was improved significantly, the KPS of 88.9% treatment group were higher than 60. Conclusions The administration of somatostatin combined with TPN is effective in the MBO due to inoperable gastrointestinal carcinoma. It can obviously relieve the symptoms of MBO and improve the quality of life in patients.
