中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
18期
24-25
,共2页
乳腺癌%血清组织多肽特异性抗原%骨桥蛋白%细针穿刺细胞学%联合检查
乳腺癌%血清組織多肽特異性抗原%骨橋蛋白%細針穿刺細胞學%聯閤檢查
유선암%혈청조직다태특이성항원%골교단백%세침천자세포학%연합검사
Breast cancer%Throttle position sensor (TPS)%Osteopontin (OPN)%Fine needle aspiration cytology%Combined detection
目的 探讨血清组织多肽特异性抗原(TPS)、骨桥蛋白(OPN)联合细针穿刺细胞学诊断早期乳腺癌的价值.方法 收集212例拟诊早期乳腺癌患者的血清肿瘤标记物TPS、OPN和细针穿刺细胞学检查资料,并与手术病理作对照,进行回顾性统计分析.结果 TPS诊断乳腺癌的敏感性为59.9％ (109/182),特异性为90.0％(27/30);OPN敏感性为62.1％ (113/182),特异性为83.3％ (25/30)；细针穿刺细胞学检查敏感性为72.5％ (132/182),特异性为96.7％ (29/30)；三项联合检查敏感性为92.3％ (168/182),特异性为76.7％ (23/30).联合检查与单一方法检查相比敏感性明显提高,阳性检出率差异有统计学意义(P＜0.01).结论 对临床疑为早期乳腺癌患者应用血清肿瘤标记物联合细针穿刺细胞学检查是发现早期乳腺癌的有效途径,具有较高的检出率和可靠的诊疗指导意义.
目的 探討血清組織多肽特異性抗原(TPS)、骨橋蛋白(OPN)聯閤細針穿刺細胞學診斷早期乳腺癌的價值.方法 收集212例擬診早期乳腺癌患者的血清腫瘤標記物TPS、OPN和細針穿刺細胞學檢查資料,併與手術病理作對照,進行迴顧性統計分析.結果 TPS診斷乳腺癌的敏感性為59.9％ (109/182),特異性為90.0％(27/30);OPN敏感性為62.1％ (113/182),特異性為83.3％ (25/30)；細針穿刺細胞學檢查敏感性為72.5％ (132/182),特異性為96.7％ (29/30)；三項聯閤檢查敏感性為92.3％ (168/182),特異性為76.7％ (23/30).聯閤檢查與單一方法檢查相比敏感性明顯提高,暘性檢齣率差異有統計學意義(P＜0.01).結論 對臨床疑為早期乳腺癌患者應用血清腫瘤標記物聯閤細針穿刺細胞學檢查是髮現早期乳腺癌的有效途徑,具有較高的檢齣率和可靠的診療指導意義.
목적 탐토혈청조직다태특이성항원(TPS)、골교단백(OPN)연합세침천자세포학진단조기유선암적개치.방법 수집212례의진조기유선암환자적혈청종류표기물TPS、OPN화세침천자세포학검사자료,병여수술병리작대조,진행회고성통계분석.결과 TPS진단유선암적민감성위59.9％ (109/182),특이성위90.0％(27/30);OPN민감성위62.1％ (113/182),특이성위83.3％ (25/30)；세침천자세포학검사민감성위72.5％ (132/182),특이성위96.7％ (29/30)；삼항연합검사민감성위92.3％ (168/182),특이성위76.7％ (23/30).연합검사여단일방법검사상비민감성명현제고,양성검출솔차이유통계학의의(P＜0.01).결론 대림상의위조기유선암환자응용혈청종류표기물연합세침천자세포학검사시발현조기유선암적유효도경,구유교고적검출솔화가고적진료지도의의.
Objective To investigate the diagnostic value of serum tumor makers throttle position sensor (TPS),Osteopontin (OPN) combined with fine needle aspiration cytology on diagnosis of early breast cancer.Methods The examination material of serum tumor markers TPS,OPN and fine needle aspiration biopsy cytology of 212 patients with early-stage breast cancer were collected.It was compared with surgery pathology and analyzed retrospectively.Results The sensitivity of TPS was 59.9％ (109/182),specificity was 90.0％ (27/30);The sensitivity of OPN was 62.1％ (113/182),specificity was 83.3％(25/30) ;The sensitivity of fine needle aspiration cytology was 72.5 ％ (132/182),specificity was 96.7％(29/30) ; The sensitivity of the three combined detection was 92.3％ (168/182),specificity was 76.7％(23/30).The sensitivity of combined detection was higher than any of them.There were sighificant differences in differences of positive rate (P ＜ 0.01).Conclusions Serum markers detection combined with fine needle aspiration cytology for early breast cancer patients with clinical suspicion is an effective way for early breast cancer detection.It has high rate of diagnosis and reliable guidance significance for diagnosis and treatment of early breast cancer.
