CAJ | 학술논문

目的观察奥美沙坦与左卡尼汀治疗中老年维持性血液透析合并心力衰竭患者的临床疗效,以及对血清炎症因子C-反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α-(TNF-α)的影响.方法选择维持性血液透析伴有心力衰竭的中老年患者56例,随机分为治疗组和对照组,每组28例,两组均行常规治疗.对照组于每次透析结束前静脉滴注左卡尼汀1.0g,治疗组在对照组治疗基础上加用奥美沙坦10 mg口服,1次/d.疗程为8周.观察患者治疗前后心功能改善情况及左室射血分数的变化,并测定各组患者血清中CRP、IL-6和TNF-α的变化.结果两组治疗前后心功能均有改善,血清炎性因子均有下降,治疗组较对照组改善更明显,差异有统计学意义(P＜0.05).结论奥美沙坦与左卡尼汀联合应用能够明显减少中老年维持性血透患者血清炎症因子水平,改善其心功能,较单用左卡尼汀效果明显.
목적 관찰오미사탄여좌잡니정치료중노년유지성혈액투석합병심력쇠갈환자적림상료효,이급대혈청염증인자C-반응단백(CRP)、백세포개소-6(IL-6)화종류배사인자-α-(TNF-α)적영향.방법 선택유지성혈액투석반유심력쇠갈적중노년환자56례,수궤분위치료조화대조조,매조28례,량조균행상규치료.대조조우매차투석결속전정맥적주좌잡니정1.0g,치료조재대조조치료기출상가용오미사탄10 mg구복,1차/d.료정위8주.관찰환자치료전후심공능개선정황급좌실사혈분수적변화,병측정각조환자혈청중CRP、IL-6화TNF-α적변화.결과 량조치료전후심공능균유개선,혈청염성인자균유하강,치료조교대조조개선경명현,차이유통계학의의(P＜0.05).결론 오미사탄여좌잡니정연합응용능구명현감소중노년유지성혈투환자혈청염증인자수평,개선기심공능,교단용좌잡니정효과명현.
Objective To observe the clinical efficacy of the olmesartan and levocarnitine on serum inflammatory cytokines CRP,IL-6 and TNF-αin middle-aged haemodialysis patients with heart failure,as well as the clinical effect on the diseasc.Methods Fifty-six middle-aged haemodialysis patients were randomly divided into control group and treatment group.The control group was injected with levocarnitine 1.0 g at the end of each haemodialysis,and the treatment group group was treated with olmesartan 10 mg,1 times every day on the basis of treatment in the control group The treatment course was 8 weeks.Before and after treatment,left ventricular ejection fraction of each group was observed and the changes of serum CRP,IL-6 and TNF-α in each group were detected.Results The cardiac function were improved in both groups after treatment,and the improvement was more obviouse in the treatment group than that in the control group,there was significant difference (P ＜ 0.05).Conclusions Olmesartan and levocarnitine can significantly improve the cardiac function in middle-aged haemodialysis patients,its mechanism may be related to the reduction of serum inflammatory cytokines in the patients.