中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
19期
50-52
,共3页
CD133蛋白%幽门螺杆菌%胃癌
CD133蛋白%幽門螺桿菌%胃癌
CD133단백%유문라간균%위암
CD133 protein%Helicobacter pylori%Gastric cancer
目的 研究胃癌组织中CD133蛋白表达及其与幽门螺杆菌(HP)感染的关系.方法 应用免疫组织化学检测62例胃癌手术切除标本及41例癌旁正常组织中CD133蛋白的表达,采用改良Giemsa染色法检测103例标本中HP感染情况,分析CD133蛋白表达在胃癌发生中的作用及其与HP感染的关系.结果 62例胃癌组织中有30例(48.4％)出现CD133蛋白阳性表达,而41例癌旁正常组织中仅有11例(26.8％)出现CD133蛋白阳性表达,差异有统计学意义(P=0.023).在有HP感染标本中CD133表达率为65.8％(50/76),而在没有HP感染标本中CD133表达率为25.9％ (7/27).经Spearman相关检验,CD133表达与幽门螺杆菌感染呈正相关(r=0.655,P＜ 0.01).结论 CD133蛋白参与了胃癌的发生发展,且与幽门螺杆菌感染密切相关.
目的 研究胃癌組織中CD133蛋白錶達及其與幽門螺桿菌(HP)感染的關繫.方法 應用免疫組織化學檢測62例胃癌手術切除標本及41例癌徬正常組織中CD133蛋白的錶達,採用改良Giemsa染色法檢測103例標本中HP感染情況,分析CD133蛋白錶達在胃癌髮生中的作用及其與HP感染的關繫.結果 62例胃癌組織中有30例(48.4％)齣現CD133蛋白暘性錶達,而41例癌徬正常組織中僅有11例(26.8％)齣現CD133蛋白暘性錶達,差異有統計學意義(P=0.023).在有HP感染標本中CD133錶達率為65.8％(50/76),而在沒有HP感染標本中CD133錶達率為25.9％ (7/27).經Spearman相關檢驗,CD133錶達與幽門螺桿菌感染呈正相關(r=0.655,P＜ 0.01).結論 CD133蛋白參與瞭胃癌的髮生髮展,且與幽門螺桿菌感染密切相關.
목적 연구위암조직중CD133단백표체급기여유문라간균(HP)감염적관계.방법 응용면역조직화학검측62례위암수술절제표본급41례암방정상조직중CD133단백적표체,채용개량Giemsa염색법검측103례표본중HP감염정황,분석CD133단백표체재위암발생중적작용급기여HP감염적관계.결과 62례위암조직중유30례(48.4％)출현CD133단백양성표체,이41례암방정상조직중부유11례(26.8％)출현CD133단백양성표체,차이유통계학의의(P=0.023).재유HP감염표본중CD133표체솔위65.8％(50/76),이재몰유HP감염표본중CD133표체솔위25.9％ (7/27).경Spearman상관검험,CD133표체여유문라간균감염정정상관(r=0.655,P＜ 0.01).결론 CD133단백삼여료위암적발생발전,차여유문라간균감염밀절상관.
Objective To study the expression of CD133 protein in gastric cancer tissue and its relationship with infection of helicobacter pylori(HP).Methods The expression levels of CD133 protein were detected by immunohistochemistry in 62 cases of surgically removed gastric cancer tissue and 41 cases of corresponding non-tumor normal tissues.The infection status of HP was detected by upgrade Giemsa staining in the tissues of 103 cases.The relationship between the infection of HP and the expression of CD133 protein was analyzed.Results The rates of positive staining for CD133 protein were 48.4％ (30/62) in carcinoma tissue,and 26.8％ (11/41) in corresponding non-tumor normal tissues,there was significant difference (P =0.023).The expression rate of CD133 protein was 65.8％ (50/76) in the tissues with HP infection,and 25.9％ (7/27) in the tissues without HP infection.CD133 protein expression was positively corTelated with infection of helicobacter pylori (r =0.655,P ＜ 0.01).Conclusions CD133 protein participate in the development of gastric cancer,and is correlated with HP infection.
