中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
20期
34-35
,共2页
妊娠高血压综合征%基质金属蛋白酶-9%血管内皮生长因子
妊娠高血壓綜閤徵%基質金屬蛋白酶-9%血管內皮生長因子
임신고혈압종합정%기질금속단백매-9%혈관내피생장인자
Hypertensive disorders in pregnancy%Matrix metallo proteinase-9%Vascular endothelial growth factor
目的 分析妊娠高血压综合征(PIH,以下简称妊高征)患者血清基质金属蛋白酶-9(MMP-9)及血管内皮生长因子(VE GF)的表达情况,探讨二者在妊高征发病中的作用及相互关系.方法 采用酶联免疫吸附(ELISA)法检测80例妊高征患者(重度25例,中度31例,轻度24例)和30例正常孕妇血清中MMP-9及VEGF的表达情况.结果 妊高征患者血清中MMP-9及VEGF低于正常妊娠对照组,轻度、中度、重度妊高征组MMP-9及VEGF与正常对照组相比差异均有统计学意义(P＜0.05),中度组低于轻度组(P＜0.05),重度组低于中度组(P＜0.05).血清MMP-9及VEGF表达呈正相关(r=0.656,P＜0.05).结论 MMP-9及VEGF参与了妊高征的病理生理改变,而且与病情严重程度有一定关系.
目的 分析妊娠高血壓綜閤徵(PIH,以下簡稱妊高徵)患者血清基質金屬蛋白酶-9(MMP-9)及血管內皮生長因子(VE GF)的錶達情況,探討二者在妊高徵髮病中的作用及相互關繫.方法 採用酶聯免疫吸附(ELISA)法檢測80例妊高徵患者(重度25例,中度31例,輕度24例)和30例正常孕婦血清中MMP-9及VEGF的錶達情況.結果 妊高徵患者血清中MMP-9及VEGF低于正常妊娠對照組,輕度、中度、重度妊高徵組MMP-9及VEGF與正常對照組相比差異均有統計學意義(P＜0.05),中度組低于輕度組(P＜0.05),重度組低于中度組(P＜0.05).血清MMP-9及VEGF錶達呈正相關(r=0.656,P＜0.05).結論 MMP-9及VEGF參與瞭妊高徵的病理生理改變,而且與病情嚴重程度有一定關繫.
목적 분석임신고혈압종합정(PIH,이하간칭임고정)환자혈청기질금속단백매-9(MMP-9)급혈관내피생장인자(VE GF)적표체정황,탐토이자재임고정발병중적작용급상호관계.방법 채용매련면역흡부(ELISA)법검측80례임고정환자(중도25례,중도31례,경도24례)화30례정상잉부혈청중MMP-9급VEGF적표체정황.결과 임고정환자혈청중MMP-9급VEGF저우정상임신대조조,경도、중도、중도임고정조MMP-9급VEGF여정상대조조상비차이균유통계학의의(P＜0.05),중도조저우경도조(P＜0.05),중도조저우중도조(P＜0.05).혈청MMP-9급VEGF표체정정상관(r=0.656,P＜0.05).결론 MMP-9급VEGF삼여료임고정적병리생리개변,이차여병정엄중정도유일정관계.
Objective To evaluate the role of matrix metallo proteinase-9 (MMP-9) and vascular endothelial growth factor(VEGF) in the pathogenesis of hypertensive disorders in pregnancy.Methods Serum MMP-9 and VEGF levels were determined in 80 patients with hypertensive disorders in pregnancy and 30 healthy pregnancy women by ELISA assay.Results Serum MMP-9 levels and VEGF were significantly lower in the patients with hypertensive disorders in pregnancy than those in healthy controls (P ＜ 0.05).Serum MMP-9 and VEGF levels in moderate PIH were significantly lower than that in mild PIH (P ＜ 0.05).Serum MMP-9 and VEGF levels in severe PIH were significantly lower than that in moderate PIH (P ＜ 0.05).Positive correlation was found between MMP-9 and VEGF expressions.Conclusions MMP-9 and VEGF may play an important role in the change of the pathophysiology of PIH and may be used as an indicato for the severity of PIH.
