CAJ | 학술논문

目的探讨复方甘草酸苷和茵栀黄颗粒联合治疗婴儿肝炎综合征的临床疗效、对细胞因子的影响及用药安全性.方法 67例婴儿肝炎综合征患儿随机分为两组,治疗组在常规综合治疗的基础上加用复方甘草酸苷和茵栀黄颗粒,对照组在常规综合治疗的基础上加用生脉注射液,并进行治疗前后血清总胆红素(TBiL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、血清电解质等测定.结果疗程结束后婴儿肝炎综合征治疗组治疗组IL-6、TNF-α下降明显,优于对照组(P＜0.05);TBiL、ALT、AST下降明显,优于对照组(P＜0.01)；治疗组和对照组总有效率分别为88.2％和63.6％,治疗组优于对照组(P＜0.05).治疗2周时两组均未见明显低钾及水钠潴留的发生.结论复方甘草酸苷和茵栀黄颗粒联合应用有助于促进婴儿肝炎综合征患儿肝功能恢复,减轻细胞因子对肝细胞的损害,无明显不良反应.
목적 탐토복방감초산감화인치황과립연합치료영인간염종합정적림상료효、대세포인자적영향급용약안전성.방법 67례영인간염종합정환인수궤분위량조,치료조재상규종합치료적기출상가용복방감초산감화인치황과립,대조조재상규종합치료적기출상가용생맥주사액,병진행치료전후혈청총담홍소(TBiL)、병안산안기전이매(ALT)、천문동안산안기전이매(AST)、혈청백세포개소-8(IL-8)、종류배사인자-α(TNF-α)、혈청전해질등측정.결과 료정결속후영인간염종합정치료조치료조IL-6、TNF-α하강명현,우우대조조(P＜0.05);TBiL、ALT、AST하강명현,우우대조조(P＜0.01)；치료조화대조조총유효솔분별위88.2％화63.6％,치료조우우대조조(P＜0.05).치료2주시량조균미견명현저갑급수납저류적발생.결론 복방감초산감화인치황과립연합응용유조우촉진영인간염종합정환인간공능회복,감경세포인자대간세포적손해,무명현불량반응.
Objective To explore the clinical efficacy and side effect of compound glycyrrhizin injection combined with yinzhihuang ghranules in treatment of infantile hepatitis syndrome,and the influence to cytokine.Methods Sixty-seven cases of infantile hepatitis syndrome were randomly divided into treatment group(n =34) and control group(n =33),both groups were treated with comprehensive therapy and to the treatment group,compound glycyrrhizin injection and yinzhihuang granules were given additionally.Shengmai injection were given additionally to the control group.The levels of serum TBiL,ALT,AST,IL-6,TNF-α and Na+,K+ were examined before and after treatment.Results There were significant differences between the two groups in the recovery of TBIL,ALT,AST (P ＜ 0.01).The levels of serum IL-6,TNF-α in the treatment group were lower than that in the control group after treatment (P ＜ 0.05).The total effective rate in the treatment group and in the control group were 88.2％ and 63.6％,respectively,and the difference between them showed significance (P ＜ 0.05).Neither remarkable hypopotassaemia nor water-sodium retention was found 2 weeks after treatment.Conclusions Compound glycyrrhizin injection combined with yinzhihuang granules has an obvious effect on the liver function recovery of infantile hepatitis syndrome,reducing the injure of cytokine to liver cells,it has no side effect in the treatment.