中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
22期
42-44
,共3页
单唾液酸神经节苷酯%硫辛酸%糖尿病周围神经病变
單唾液痠神經節苷酯%硫辛痠%糖尿病週圍神經病變
단타액산신경절감지%류신산%당뇨병주위신경병변
Single sialic acid ganglioside%Lipoic acid%Diabetic peripheral neuropathy
目的 对单唾液酸神经节苷酯联合硫辛酸多靶点治疗老年2型糖尿病周围神经病变的疗效进行分析.方法 将80例老年2型糖尿病周围神经病变患者随机分为两组,对照组40例,治疗组40例.对照组在常规治疗的基础上加用弥可保,治疗组加用硫辛酸和单唾液酸神经节苷酯,两组疗程均为3周.治疗前后测正中神经、腓总神经的运动传导速度及感觉传导速度,并且测定患者血清C-反应蛋白浓度.结果 治疗组总有效率为85.0％,对照组总有效率为67.5％,两组比较差异有统计学意义(P＜0.05)；治疗组治疗后正中神经、腓总神经的运动传导速度及感觉传导速度明显加快,优于对照组(P＜0.05)；治疗组C-反应蛋白降低程度明显优于对照组(P＜0.05).结论 单唾液酸神经节苷酯联合硫辛酸可以多靶点治疗老年2型糖尿病周围神经病变,值得临床推广.
目的 對單唾液痠神經節苷酯聯閤硫辛痠多靶點治療老年2型糖尿病週圍神經病變的療效進行分析.方法 將80例老年2型糖尿病週圍神經病變患者隨機分為兩組,對照組40例,治療組40例.對照組在常規治療的基礎上加用瀰可保,治療組加用硫辛痠和單唾液痠神經節苷酯,兩組療程均為3週.治療前後測正中神經、腓總神經的運動傳導速度及感覺傳導速度,併且測定患者血清C-反應蛋白濃度.結果 治療組總有效率為85.0％,對照組總有效率為67.5％,兩組比較差異有統計學意義(P＜0.05)；治療組治療後正中神經、腓總神經的運動傳導速度及感覺傳導速度明顯加快,優于對照組(P＜0.05)；治療組C-反應蛋白降低程度明顯優于對照組(P＜0.05).結論 單唾液痠神經節苷酯聯閤硫辛痠可以多靶點治療老年2型糖尿病週圍神經病變,值得臨床推廣.
목적 대단타액산신경절감지연합류신산다파점치료노년2형당뇨병주위신경병변적료효진행분석.방법 장80례노년2형당뇨병주위신경병변환자수궤분위량조,대조조40례,치료조40례.대조조재상규치료적기출상가용미가보,치료조가용류신산화단타액산신경절감지,량조료정균위3주.치료전후측정중신경、비총신경적운동전도속도급감각전도속도,병차측정환자혈청C-반응단백농도.결과 치료조총유효솔위85.0％,대조조총유효솔위67.5％,량조비교차이유통계학의의(P＜0.05)；치료조치료후정중신경、비총신경적운동전도속도급감각전도속도명현가쾌,우우대조조(P＜0.05)；치료조C-반응단백강저정도명현우우대조조(P＜0.05).결론 단타액산신경절감지연합류신산가이다파점치료노년2형당뇨병주위신경병변,치득림상추엄.
Objective To analyze the effect of single sialic acid ganglioside combined with lipoic acid on elderly patients with type 2 diabetic peripheral neuropathy (DNP).Methods Eighty elderly patients with type 2 DNP were randomly divided into two groups,the control group (40 cases) and the treatment group (40 cases).Patients in control group were treated with methycobal on the basis of conventional treatment,while patients in treatment group were treated with single sialic acid ganglioside combined with lipoic acid on the basis of conventional treatment.They were treated for three weeks.The motor conduction velocity (MCV) and sensory conduction velocity (SCV) of the median nerve and common peroneal nerve were detected before and after treatment.The C reactive protein (CRP) levels were also detected.Results The total efficiency rates were 85.0％ in the treatment group and 67.5％ in the control group,there was significant difference (P ＜ 0.05).The MCV and SCV of the median nerve and common peroneal verve improved after treatment,while the treatment group was superior to the control group (P ＜ 0.05).The CRP level of the treatment decreased more than that of the control group (P ＜ 0.05).Conclusions Single sialic acid ganglioside combined with lipoic acid is worthy of clinical application.
