CAJ | 학술논문

目的探讨急性ST段抬高性心肌梗死(STEMI)患者急诊介入术中血小板活化因子(PAF)与血栓抽吸的关系.方法选择2009年6月至2011年9月STEMI患者100例,其中急诊介入术(PCI)加血栓抽吸治疗者为血栓抽吸组(50例),同时期条件相当仅行急诊介入治疗患者作为标准PCI组(50例),比较两组的基础资料及PAF情况.结果两组术后PAF比术前明显升高(P＜0.05),且血栓抽吸组低于普通PCI组；在血栓负荷大的患者中PAF水平更高.结论 STEMI急诊PCI术中血栓抽吸可以降低PAF水平,减少微小血管的血小板活化和聚集,改善梗死部位心肌水平的血液灌注.
목적 탐토급성ST단태고성심기경사(STEMI)환자급진개입술중혈소판활화인자(PAF)여혈전추흡적관계.방법 선택2009년6월지2011년9월STEMI환자100례,기중급진개입술(PCI)가혈전추흡치료자위혈전추흡조(50례),동시기조건상당부행급진개입치료환자작위표준PCI조(50례),비교량조적기출자료급PAF정황.결과 량조술후PAF비술전명현승고(P＜0.05),차혈전추흡조저우보통PCI조；재혈전부하대적환자중PAF수평경고.결론 STEMI급진PCI술중혈전추흡가이강저PAF수평,감소미소혈관적혈소판활화화취집,개선경사부위심기수평적혈액관주.
Objective To investigate the relationship between thrombus-aspiration and platelet activating factor (PAF) during emergency percutaneous coronary intervention(PCI) in patients with acute ST segment elevation myocardial infarction(STEMI).Methods One hundred STEMI patients underwent emergent PCI from June 2009 to September 2011 were choosed,50 patients received thrombus aspiration were enrolled in study group,and 50 patients who only received routine PCI were enrolled in control group.The clinical data and the PAF levels were compared between the two groups.Results The PAF levels increased after PCI in both groups (P ＜ 0.05).Compared with control group,patients in thrombus aspiration group had lower serum PAF level; The level of serum PAF was higher in the patients complicated with thrombus burden.Conclusions Thrombus-aspiration can lower the level of PAF,decrease the platelet aggregation and activation in micro-vascular vessel and improve myocardium blood perfusion in infarction area during emergency PCI in patients with STEMI.