中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
22期
67-70
,共4页
多囊卵巢综合征%视黄醇结合蛋白4%中性粒细胞明胶酶相关脂质运载蛋白%炎症
多囊卵巢綜閤徵%視黃醇結閤蛋白4%中性粒細胞明膠酶相關脂質運載蛋白%炎癥
다낭란소종합정%시황순결합단백4%중성립세포명효매상관지질운재단백%염증
Polycystic ovary syndrome%Retinol binding protein 4%Neutrophil gelatinase associated lipocalin%Inflammation
目的 探讨多囊性卵巢综合征(PCOS)患者血清中视黄醇结合蛋白4(RBP4)和中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的浓度与临床意义.方法 对96例PCOS患者及30例正常对照组患者分别采用酶联免疫(ELISA)法检测血清RBP4和NGAL含量；同时根据体质量指数(BMI)将PCOS患者分为肥胖组50例(BMI≥25 kg/m2)和非肥胖组46例(BMI＜ 25 kg/m2).结果 ①肥胖及非肥胖PCOS患者血清中RBP4和NGAL含量均明显高于正常对照组(￡=11.27,8.59,10.75,8.23,P均＜0.05),肥胖PCOS患者血清中RBP4和NGAL含量均明显高于非肥胖PCOS患者(t=7.68,7.25,P均＜0.05)；②Pearson相关分析显示,RBP4与NGAL、BMI及胰岛素抵抗指数(HOMA-IR)呈正相关(P ＜0.05); NGAL与BMI及HOMA-IR呈正相关(P＜0.05).结论 PCOS患者机体内可能存在着一种慢性炎症状态,可能是引起PCOS患者血清RBP4和NGAL水平的升高的原因.
目的 探討多囊性卵巢綜閤徵(PCOS)患者血清中視黃醇結閤蛋白4(RBP4)和中性粒細胞明膠酶相關脂質運載蛋白(NGAL)的濃度與臨床意義.方法 對96例PCOS患者及30例正常對照組患者分彆採用酶聯免疫(ELISA)法檢測血清RBP4和NGAL含量；同時根據體質量指數(BMI)將PCOS患者分為肥胖組50例(BMI≥25 kg/m2)和非肥胖組46例(BMI＜ 25 kg/m2).結果 ①肥胖及非肥胖PCOS患者血清中RBP4和NGAL含量均明顯高于正常對照組(￡=11.27,8.59,10.75,8.23,P均＜0.05),肥胖PCOS患者血清中RBP4和NGAL含量均明顯高于非肥胖PCOS患者(t=7.68,7.25,P均＜0.05)；②Pearson相關分析顯示,RBP4與NGAL、BMI及胰島素牴抗指數(HOMA-IR)呈正相關(P ＜0.05); NGAL與BMI及HOMA-IR呈正相關(P＜0.05).結論 PCOS患者機體內可能存在著一種慢性炎癥狀態,可能是引起PCOS患者血清RBP4和NGAL水平的升高的原因.
목적 탐토다낭성란소종합정(PCOS)환자혈청중시황순결합단백4(RBP4)화중성립세포명효매상관지질운재단백(NGAL)적농도여림상의의.방법 대96례PCOS환자급30례정상대조조환자분별채용매련면역(ELISA)법검측혈청RBP4화NGAL함량；동시근거체질량지수(BMI)장PCOS환자분위비반조50례(BMI≥25 kg/m2)화비비반조46례(BMI＜ 25 kg/m2).결과 ①비반급비비반PCOS환자혈청중RBP4화NGAL함량균명현고우정상대조조(￡=11.27,8.59,10.75,8.23,P균＜0.05),비반PCOS환자혈청중RBP4화NGAL함량균명현고우비비반PCOS환자(t=7.68,7.25,P균＜0.05)；②Pearson상관분석현시,RBP4여NGAL、BMI급이도소저항지수(HOMA-IR)정정상관(P ＜0.05); NGAL여BMI급HOMA-IR정정상관(P＜0.05).결론 PCOS환자궤체내가능존재착일충만성염증상태,가능시인기PCOS환자혈청RBP4화NGAL수평적승고적원인.
Objective To investigate concentration and clinical significance of serum retinol binding protein 4 (RBP4) and neutrophil gelatinase associated lipocalin (NGAL) in patients with polycystic ovary syndrome(PCOS).Methods Ninety-six PCOS patients and 30 healthy women with body mass index (BMI) ＜25 kg/m2 as controls were recruited.PCOS patients were divided into two groups:50 patients BMI≥25 kg/m2 as obese group; 46 patients BMI ＜25 kg/m2 as non-obese group.The concentrations of RBP4 and NGAL were measured by enzyme-linked immunosorbent assay (ELISA).Results ①Obese and non-obese PCOS group RBP4 and NGAL were higher than control group (t =11.27,8.59,10.75,8.23,P ＜ 0.05),and the RBP4 and NGAL were higher in the obese PCOS group than non-obese PCOS group (t =7.68,7.25,P ＜ 0.05).②Pearson correlatien analysis revealed that the serum levels of RBP4 and NGAL were significantly and positively correlated with BMI and HOMA-IR (P ＜ 0.05) ; The serum levels of RBP4 was positively correlated with NGAL (P ＜ 0.05).Conclusions Chronic inflammation maybe exists in patients with PCOS.RBP4 and NGAL may be a predictor factor in patients with PCOS.
