中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
22期
70-72
,共3页
王卫华%张永葆%徐均陶%韦俊超%张业敏%葛伟
王衛華%張永葆%徐均陶%韋俊超%張業敏%葛偉
왕위화%장영보%서균도%위준초%장업민%갈위
脑白质疏松%颈动脉内中膜厚度%高敏C-反应蛋白%老年患者
腦白質疏鬆%頸動脈內中膜厚度%高敏C-反應蛋白%老年患者
뇌백질소송%경동맥내중막후도%고민C-반응단백%노년환자
Leukoaraiosis%Iintima media thickness of carotid%High-sensitivity C-reactive protein%Elderly patient
目的 探讨老年患者脑白质疏松(LA)程度与颈动脉内中膜厚度(CAMIT)、血清高敏C-反应蛋白(hs-CRP)之间的相关性.方法 选取老年LA患者81例,根据头颅MRI脑白质疏松程度分为三组:LA 1级组32例,LA 2级组23例,LA 3级组26例.选取同期健康体检无脑白质疏松的老年人32例为对照组,分别测定各组受试者空腹血糖(FBG)、总胆固醇(CHOL)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血尿酸(UA)、hs-CRP水平及CAIMT.结果 LA 1级组、2级组、3级组与对照组比较:CAIMT差异均有统计学意义(P＜0.05),LA 1级组与3级组比较差异有统计学意义(P ＜0.05);LA2级组与3级组hs-CRP水平与对照组比较差异有统计学意义(P＜0.05),LA 1级组与LA 3级组比较差异有统计学意义(P＜0.05)；hs-CRP、CAIMT相关性分析显示CAIMT与C-反应蛋白水平呈正相关(r=0.879,P＜0.01).结论 hs-CRP介导的炎症反应及颈动脉硬化导致的慢性脑缺血可能参与了LA的发病机制；hs-CRP、CAMIT与脑白质疏松的程度密切相关.
目的 探討老年患者腦白質疏鬆(LA)程度與頸動脈內中膜厚度(CAMIT)、血清高敏C-反應蛋白(hs-CRP)之間的相關性.方法 選取老年LA患者81例,根據頭顱MRI腦白質疏鬆程度分為三組:LA 1級組32例,LA 2級組23例,LA 3級組26例.選取同期健康體檢無腦白質疏鬆的老年人32例為對照組,分彆測定各組受試者空腹血糖(FBG)、總膽固醇(CHOL)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血尿痠(UA)、hs-CRP水平及CAIMT.結果 LA 1級組、2級組、3級組與對照組比較:CAIMT差異均有統計學意義(P＜0.05),LA 1級組與3級組比較差異有統計學意義(P ＜0.05);LA2級組與3級組hs-CRP水平與對照組比較差異有統計學意義(P＜0.05),LA 1級組與LA 3級組比較差異有統計學意義(P＜0.05)；hs-CRP、CAIMT相關性分析顯示CAIMT與C-反應蛋白水平呈正相關(r=0.879,P＜0.01).結論 hs-CRP介導的炎癥反應及頸動脈硬化導緻的慢性腦缺血可能參與瞭LA的髮病機製；hs-CRP、CAMIT與腦白質疏鬆的程度密切相關.
목적 탐토노년환자뇌백질소송(LA)정도여경동맥내중막후도(CAMIT)、혈청고민C-반응단백(hs-CRP)지간적상관성.방법 선취노년LA환자81례,근거두로MRI뇌백질소송정도분위삼조:LA 1급조32례,LA 2급조23례,LA 3급조26례.선취동기건강체검무뇌백질소송적노년인32례위대조조,분별측정각조수시자공복혈당(FBG)、총담고순(CHOL)、삼선감유(TG)、저밀도지단백(LDL)、고밀도지단백(HDL)、혈뇨산(UA)、hs-CRP수평급CAIMT.결과 LA 1급조、2급조、3급조여대조조비교:CAIMT차이균유통계학의의(P＜0.05),LA 1급조여3급조비교차이유통계학의의(P ＜0.05);LA2급조여3급조hs-CRP수평여대조조비교차이유통계학의의(P＜0.05),LA 1급조여LA 3급조비교차이유통계학의의(P＜0.05)；hs-CRP、CAIMT상관성분석현시CAIMT여C-반응단백수평정정상관(r=0.879,P＜0.01).결론 hs-CRP개도적염증반응급경동맥경화도치적만성뇌결혈가능삼여료LA적발병궤제；hs-CRP、CAMIT여뇌백질소송적정도밀절상관.
Objective To investigate the correlationship between the degree of leukoaraiosis (LA) with intima media thickness of carotid (CAMIT) and high-sensitivity C-reactive protein (hs-CRP)in elderly patients.Methods Eighty-one elderly patients with LA were divided into three groups according to the degree of leukoaraiosis detected by magnetic resonance imaging (MRI),32 cases were in LA level 1 group,23 cases were in LA level 2 group,26 cases were in LA level 3 group.Thirty-two healthy elderly people without LA were in control group.The differences were compared between the four groups in FBG,CHOL,TG,LDL,HDL,UA,hs-CRP and CAIMT.Results The CAIMT of LA patients were significantly higher than those of control group (P ＜ 0.05),there was significant difference between LA 1 level group and 3 level group (P ＜ 0.05),the hs-CRP levels of LA level 1 group and level 2 group were significant different (P ＜ 0.05) with controls,there were significantly difference (P ＜ 0.05) between LA level 1 group and level 3 group.The correlation analysis showed CAIMT was positively correlated with hs-CRP (r =0.879,P ＜0.01).Conclusions hs-CRP and carotid atherosclerosis may play an important pole in the pathogenesis of LA,CAMIT and hs-CRP were closely correlated with the degree of leukoaraiosis.
