中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
23期
9-10
,共2页
四联疗法%Hp感染%消化性溃疡%小儿%疗效%安全性
四聯療法%Hp感染%消化性潰瘍%小兒%療效%安全性
사련요법%Hp감염%소화성궤양%소인%료효%안전성
Quadruple therapy%Hp infection%Peptic ulcers%Children%Curative effect%Safety
目的 观察四联疗法治疗小儿伴幽门螺杆菌(Hp)感染消化性溃疡的疗效及安全性.方法 将番禺区石碁人民医院2011年2月至2012年2月66例伴Hp感染消化性溃疡的患儿随机分为两组,四联组33例患儿采用四联疗法治疗；另33例患儿采用三联疗法治疗,对两种不同方法的疗效及安全性进行观察.结果 四联组治愈28例,有效4例,总有效率为96.97％,Hp根除32例,根除率96.97％；三联组治愈23例,有效3例,总有效率为78.79％,Hp根除率为78.79％；两组比较差异有统计学意义(P＜0.05).四联组共出现不良反应4例,分别为恶心、呕吐2例,头晕、乏力1例,腹胀纳差1例,不良反应发生率为12.12％；三联组共出现不良反应12例,分别为恶心、呕吐7例,头晕、乏力3例,腹胀纳差2例,不良反应发生率为36.36％；四联组不良反应发生率明显低于三联组,两组比较差异有统计学意义(P＜0.05).结论 四联疗法治疗小儿伴Hp感染消化性溃疡具有疗效好、不良反应小、患儿耐受性好等优点.
目的 觀察四聯療法治療小兒伴幽門螺桿菌(Hp)感染消化性潰瘍的療效及安全性.方法 將番禺區石碁人民醫院2011年2月至2012年2月66例伴Hp感染消化性潰瘍的患兒隨機分為兩組,四聯組33例患兒採用四聯療法治療；另33例患兒採用三聯療法治療,對兩種不同方法的療效及安全性進行觀察.結果 四聯組治愈28例,有效4例,總有效率為96.97％,Hp根除32例,根除率96.97％；三聯組治愈23例,有效3例,總有效率為78.79％,Hp根除率為78.79％；兩組比較差異有統計學意義(P＜0.05).四聯組共齣現不良反應4例,分彆為噁心、嘔吐2例,頭暈、乏力1例,腹脹納差1例,不良反應髮生率為12.12％；三聯組共齣現不良反應12例,分彆為噁心、嘔吐7例,頭暈、乏力3例,腹脹納差2例,不良反應髮生率為36.36％；四聯組不良反應髮生率明顯低于三聯組,兩組比較差異有統計學意義(P＜0.05).結論 四聯療法治療小兒伴Hp感染消化性潰瘍具有療效好、不良反應小、患兒耐受性好等優點.
목적 관찰사련요법치료소인반유문라간균(Hp)감염소화성궤양적료효급안전성.방법 장번우구석기인민의원2011년2월지2012년2월66례반Hp감염소화성궤양적환인수궤분위량조,사련조33례환인채용사련요법치료；령33례환인채용삼련요법치료,대량충불동방법적료효급안전성진행관찰.결과 사련조치유28례,유효4례,총유효솔위96.97％,Hp근제32례,근제솔96.97％；삼련조치유23례,유효3례,총유효솔위78.79％,Hp근제솔위78.79％；량조비교차이유통계학의의(P＜0.05).사련조공출현불량반응4례,분별위악심、구토2례,두훈、핍력1례,복창납차1례,불량반응발생솔위12.12％；삼련조공출현불량반응12례,분별위악심、구토7례,두훈、핍력3례,복창납차2례,불량반응발생솔위36.36％；사련조불량반응발생솔명현저우삼련조,량조비교차이유통계학의의(P＜0.05).결론 사련요법치료소인반Hp감염소화성궤양구유료효호、불량반응소、환인내수성호등우점.
Objective To observe the effect and safety of quadruple therapy in treatment of children with Hp infection and peptic ulcer.Methods Sixty-six patients with Hp infection and peptic ulcer admitted in Shiqi people's hospital from February 2011 to February 2012 were randomly divided into two groups,33 children recieved quadruple therapy (quadruple therapy group); another 33 children were treated by triple therapy (triple therapy group).The efficacy and safety of the two methods were observed.Results In quadruple therapy group,28 cases were cured,effective in 4 cases,the total effective rate was 96.97％,Hp eradication in 32 cases,the eradication rate was 96.97％ ; In triple therapy group,23 cases were cured,effective in 3 cases,the total effective rate was 78.79％,Hp eradication rate was 78.79％ ; the differences between the two groups were significant (P ＜ 0.05).In quadruple therapy group,4 cases had adverse drug reactions,including 2 cases of nausea and vomiting,1 case of dizziness and weakness,1 case of abdominal distension,the incidence of adverse reactions was 12.12％ ; In triple group,12 cases had adverse drug reactions,including 7 cases of nausea and vomiting,3 cases of dizziness and weakness,2 cases of abdominal distension,the adverse reaction rate was 36.36％.The incidence of adverse reactions in quadruple therapy group was significantly lower than that in triple therapy group,the difference between the two groups was significant (P ＜ 0.05).Conclusions Quadruple therapy in treatment of children with Hp infection and peptic ulcer disease has good curative effect,less adverse reactions and good tolerance.
