中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
23期
49-51
,共3页
降钙素原%医院感染%ICU%重度有机磷中毒
降鈣素原%醫院感染%ICU%重度有機燐中毒
강개소원%의원감염%ICU%중도유궤린중독
Procalcitonin%Nosocomial infection%ICU%Severe organophosphorus poisoning
目的 探讨血清降钙素原(procalcitonin,PCT)测定在重症监护病房(ICU)重度有机磷中毒患者医院感染中的临床意义.方法 选取重度有机磷中毒患者107例,采用半定量固相免疫色谱法(PCT-Q)动态监测血清PCT浓度,同时分析医院感染的情况.结果 ICU重毒有机磷中毒患者医院感染率为43.8％,感染组与对照组血清PCT浓度比较差异有统计学意义(P＜0.01),PCT＞0.5 ng/ml预测医院感染的敏感度、特异度、阳性预测值、阴性预测值分别为95.65％、81.83％、80％、96.15％.对PCT阳性患者使用适当抗生素治疗3～7 d后,PCT转为正常(＜0.5 ng/ml).结论 血清降钙素原测定对ICU重毒有机磷中毒患者院内感染早期诊断及临床抗生素治疗有指导意义.
目的 探討血清降鈣素原(procalcitonin,PCT)測定在重癥鑑護病房(ICU)重度有機燐中毒患者醫院感染中的臨床意義.方法 選取重度有機燐中毒患者107例,採用半定量固相免疫色譜法(PCT-Q)動態鑑測血清PCT濃度,同時分析醫院感染的情況.結果 ICU重毒有機燐中毒患者醫院感染率為43.8％,感染組與對照組血清PCT濃度比較差異有統計學意義(P＜0.01),PCT＞0.5 ng/ml預測醫院感染的敏感度、特異度、暘性預測值、陰性預測值分彆為95.65％、81.83％、80％、96.15％.對PCT暘性患者使用適噹抗生素治療3～7 d後,PCT轉為正常(＜0.5 ng/ml).結論 血清降鈣素原測定對ICU重毒有機燐中毒患者院內感染早期診斷及臨床抗生素治療有指導意義.
목적 탐토혈청강개소원(procalcitonin,PCT)측정재중증감호병방(ICU)중도유궤린중독환자의원감염중적림상의의.방법 선취중도유궤린중독환자107례,채용반정량고상면역색보법(PCT-Q)동태감측혈청PCT농도,동시분석의원감염적정황.결과 ICU중독유궤린중독환자의원감염솔위43.8％,감염조여대조조혈청PCT농도비교차이유통계학의의(P＜0.01),PCT＞0.5 ng/ml예측의원감염적민감도、특이도、양성예측치、음성예측치분별위95.65％、81.83％、80％、96.15％.대PCT양성환자사용괄당항생소치료3～7 d후,PCT전위정상(＜0.5 ng/ml).결론 혈청강개소원측정대ICU중독유궤린중독환자원내감염조기진단급림상항생소치료유지도의의.
Objective To explore the clinical significance of serum procalcitonin (PCT) levels in severe organophosphorus poisoning patients with nosocomial infection in ICU.Methods One hundred and seven patients were selected and monitored PCT concentration using semiquantitative solidphase immune chomatography(PCT-Q) and nosocomial infection.Results The rate of nosocomial infection was 43％ in severe organophosphorus poisoning patients.The difference of PCT concentration was statistically significant (P ＜ 0.01) between infection group and control group.The sensitivity,specificity,and positive and negative predictive values of nosocomial infection prediction with PCT ＞ 0.5 ng/ml were 95.65％,81.83％,80％ and 96.15％,respectively.PCT values returned to normal(＜0.5 ng/ml) by 3 to 7 days of appropriate antibiotic therapy.Conclusions For severe organophosphorus poisoning patients in ICU,monitoring PCT level could help find and distinguish nosocomial infection at an earlier stage and guide the application of antibiotics.
