中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
23期
56-58
,共3页
颈动脉粥样硬化斑块%脑梗死%药物治疗%阿托伐他汀
頸動脈粥樣硬化斑塊%腦梗死%藥物治療%阿託伐他汀
경동맥죽양경화반괴%뇌경사%약물치료%아탁벌타정
Carotid atherosclerosis plaques%Cerebral stroke%Medication therapy%Atorvastatin
目的 评价阿托伐他汀在治疗颈动脉粥样硬化斑块中的临床价值.方法 将巩义市人民医院收治的192例经彩超检测存在颈动脉粥样硬化及斑块形成的脑梗死患者随机分为对照组和治疗组,每组96例,对照组予以口服抗血小板药物阿司匹林100 mg/d,并采取控制血压和血糖等措施,治疗组在对照组的基础上予以阿托伐他汀20 mg/d.6个月为1个疗程,治疗2个疗程,并对两组患者治疗前、治疗6个月和12个月后的颈动脉内膜-中层厚度、斑块面积及斑块性质数量进行比较.结果 两组患者在治疗后6个月和治疗后12个月的颈动脉内膜-中层厚度和斑块面积显著低于治疗前(P＜0.05).而治疗组在治疗后6个月和治疗后12个月的颈动脉内膜-中层厚度和斑块面积显著低于同期对照组(P＜0.05).两组患者在治疗6个月和12个月后两组扁平斑、硬斑及混合斑的数量比较差异无统计学意义(P＞0.05),但治疗组的软斑数量显著少于治疗前(P＜0.05).结论 阿托伐他汀能够有效地降低血脂水平,不仅缺血性脑血管病患者颈动脉硬化的程度得到减缓,还可以起到稳定斑块的作用.
目的 評價阿託伐他汀在治療頸動脈粥樣硬化斑塊中的臨床價值.方法 將鞏義市人民醫院收治的192例經綵超檢測存在頸動脈粥樣硬化及斑塊形成的腦梗死患者隨機分為對照組和治療組,每組96例,對照組予以口服抗血小闆藥物阿司匹林100 mg/d,併採取控製血壓和血糖等措施,治療組在對照組的基礎上予以阿託伐他汀20 mg/d.6箇月為1箇療程,治療2箇療程,併對兩組患者治療前、治療6箇月和12箇月後的頸動脈內膜-中層厚度、斑塊麵積及斑塊性質數量進行比較.結果 兩組患者在治療後6箇月和治療後12箇月的頸動脈內膜-中層厚度和斑塊麵積顯著低于治療前(P＜0.05).而治療組在治療後6箇月和治療後12箇月的頸動脈內膜-中層厚度和斑塊麵積顯著低于同期對照組(P＜0.05).兩組患者在治療6箇月和12箇月後兩組扁平斑、硬斑及混閤斑的數量比較差異無統計學意義(P＞0.05),但治療組的軟斑數量顯著少于治療前(P＜0.05).結論 阿託伐他汀能夠有效地降低血脂水平,不僅缺血性腦血管病患者頸動脈硬化的程度得到減緩,還可以起到穩定斑塊的作用.
목적 평개아탁벌타정재치료경동맥죽양경화반괴중적림상개치.방법 장공의시인민의원수치적192례경채초검측존재경동맥죽양경화급반괴형성적뇌경사환자수궤분위대조조화치료조,매조96례,대조조여이구복항혈소판약물아사필림100 mg/d,병채취공제혈압화혈당등조시,치료조재대조조적기출상여이아탁벌타정20 mg/d.6개월위1개료정,치료2개료정,병대량조환자치료전、치료6개월화12개월후적경동맥내막-중층후도、반괴면적급반괴성질수량진행비교.결과 량조환자재치료후6개월화치료후12개월적경동맥내막-중층후도화반괴면적현저저우치료전(P＜0.05).이치료조재치료후6개월화치료후12개월적경동맥내막-중층후도화반괴면적현저저우동기대조조(P＜0.05).량조환자재치료6개월화12개월후량조편평반、경반급혼합반적수량비교차이무통계학의의(P＞0.05),단치료조적연반수량현저소우치료전(P＜0.05).결론 아탁벌타정능구유효지강저혈지수평,불부결혈성뇌혈관병환자경동맥경화적정도득도감완,환가이기도은정반괴적작용.
Objective To evaluate the clinical value of atorvastatin in treatment of carotid atherosclerosis plaques.Methods One hundred and ninty-two patients who were diagnosed as cerebral stroke caused by carotid atherosclerosis plaques via check of color doppler sonography were divided into treatment group and control group randomly,with 96 cases in each group.Patients in control groups were given persral antiplatelet agents(aspirin) 100 mg/d,and were taken measure to control blood pressure and blood sugar.Patients in treatment group were given atorvastatin 20 mg/d besides the same treatment as control groups.One course of treatment was 6 months,all patients receives two courses of treatment.Carotid artery intima-media thickness,area of plaque and quantity of plaques were compared between the two groups at the time of before treatment,one course of treatment and two courses of treatment.Results Carotid artery intima-media thickness and area of plaques at the time of one course and two courses of treatment were lower than the time of before treatment significantly (P ＜ 0.05),and treatment group were lower than control groups significantly (P ＜ 0.05).The quantity of applanate plaques,hard plaques and compound plaques in two groups at the time of one course and two courses of treatment showed no statistical significance (P ＞ 0.05),soft plaques in treatment were less than control group (P ＜ 0.05).Conclusions Atorvastatin could lower blood lipid levels effectively not only slow down the degree of carotid atherosclerosis,and can stabilize the extension of plaques.
